• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Phase 1 Clinical Pharmacology Studies
【24h】

Phase 1 Clinical Pharmacology Studies

机译：第1阶段临床药理学研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Six Phase I clinical pharmacology studies were performed during this contractperiod under the Task Order numbers 90-01, 92-04, 92-05, 94-06, 94-07 and 94-09. Task Order 90-01 produced data suggesting that the Mark I auto-injector produced effective and desirable blood levels and effects of atropine and 2-PAM compared to other prototype auto-injectors. Task Order 92-04 demonstrated that WR 238, 605 was safe and well tolerated at single doses up to 600 mg. Task Order 92-05 compared the blood levels produced by a new dosing regimen for halofantrine in the fed compared to the fasting state. Task Order 94-06 demonstrated the lack of irritating potential for a topical skin protectant. Task Order 94-07 demonstrated the safety of weekly dosing with the antimalarial WR 238, 605 and documented the accumulation of non toxic methemoglobin levels at the higher doses. This side effect may be beneficial in prophylaxis against cyanide poisoning. Task Order 94-09 showed a lack of toxicity from multiple dose pyridostigmine bromide in healthy male and female subjects of different weights.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号