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Role of Matrilysin, A Matrix Metalloproteinase, in Mammary Tumorigenesis

机译：基质金属蛋白酶基质蛋白酶在乳腺肿瘤发生中的作用

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The processes of mammary gland development and mammary tumor growth requireextensive remodeling of the extracellular matrix (ECM). Proteins that degrade the ECM such as matrix metalloproteinases (MMPs), are important during these and several other matrix degrading processes. We hypothesized that an epithelial specific MMP, matrilysin (MAT), is partly responsible for remodeling of the ECM during mammary development and tumorigenesis. To test our hypothesis, transgenic mice expressing MAT under the control of the mouse mammary tumor virus (MMTV) promoter/enhancer were generated to investigate if overproduction of MAT alters mammary development and/or mammary tumorigenesis. In this report, we show that although overexpression of MAT does not alter normal mammary development, the presence of MAT does induce premature milk production in normal transgenic mammary glands. In addition, the expression of MAT in MMTV-Mat/neu double transgenic animals accelerates the onset and frequency of mammary tumorigenesis.

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作者
Matrisian, L. M.; Rudolph, L. A.;
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年度 1997
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总页数 22
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Neoplasms; Mammary glands; Breast cancer; Frequency; Proteins; Animals; Hypotheses; Mice; Viruses; Genetics; Growth(Physiology); Mats; Metastasis;

机译：肿瘤;乳腺;乳腺癌;频率;蛋白质;动物;假说;小鼠;病毒;遗传学;生长（生理学）;垫;转移;

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专利

1. Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis. [J] . Newell KJ, Matrisian LM, Driman DK Molecular Carcinogenesis . 2002,第2期

机译：溃疡性结肠炎相关的肿瘤发生中基质溶素（matrix metalloproteinase-7）的表达。
2. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. [J] . Ii M, Yamamoto H, Adachi Y, Experimental Biology and Medicine: Journal of the Society for Experimental Biology and Medicine . 2006,第1期

机译：基质金属蛋白酶7（基质溶素）在人类癌症侵袭，凋亡，生长和血管生成中的作用。
3. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression. [J] . Yamamoto H, Itoh F, Iku S, Journal of Clinical Oncology . 2001,第4期

机译：基质金属蛋白酶和金属蛋白酶组织抑制剂在人胰腺腺癌中的表达：基质溶素的临床病理和预后意义。
4. THE ROLE OF MATRIX METALLOPROTEINASES (MMPs) AND TISSUE INHIBITORS OF METALLOPROTEINASES (TIMPs) IN MESANGIAL MATRIX REPLACEMENT IN AL-AMYLOiDOSIS: AN 1N-VIVO AND IN-VITRO CORRELATIVE STUDY [C] . J. Keeling, S. Dempse, L. Joseph, International Symposium on Amyloidosis . 2005

机译：基质金属蛋白酶（MMP）和组织抑制剂的作用（MMP）和组织抑制剂在亚氨基化症中的Mesangial基质中的替代性：1N-体内和体外相关研究
5. The role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovulation. [D] . Bakke, Leanne Joy. 2002

机译：基质金属蛋白酶和金属蛋白酶组织抑制剂在排卵中的作用。
6. Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility [O] . Laura A. Rudolph-Owen, Paul Cannon, Lynn M. Matrisian 1998

机译：基质金属蛋白酶Matrilysin的过表达导致乳腺过早分化和男性不育
7. Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility [O] . Rudolph-Owen, Laura A., Cannon, Paul, Matrisian, Lynn M. 1998

机译：基质金属蛋白酶Matrilysin的过表达导致乳腺过早分化和男性不育

Role of Matrilysin, A Matrix Metalloproteinase, in Mammary Tumorigenesis

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