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Toxicology of Ethylene Oxide Derivatives: the Skin Sensitizing Potential of Heptanal (Final Report) with Attachment and Cover Letter Dated 12/02/1991

机译：环氧乙烷衍生物的毒理学：庚醛的皮肤敏感潜力（最终报告）附件和求职信日期：12/02/1991

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Heptanal (CAS No. 111-71-7) was evaluated for dermal sensitization in the guinea-pig maximization test of Magnusson and Kligman. The test substance was applied at a dosage of 0.1 ml to the shoulder region of 10 male and 10 female guinea pigs ('P' strain). One test animal died before induction and another was sacrificed because it had lost 27% of its initial body weight. Therefore, only 18 rabbits were included in the challenge procedure. Two weeks after induction, a challenge patch of 0.1 ml of test substance was applied at a previously untreated site under occlusive wrap. Results of the challenge procedure include 4 animals that showed a positive response after 24-hours and 3 animals that showed positive responses after 48 hours.

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年度 1991
页码 p.1-17
总页数 17
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicology; Health effects; Heptanal (111-71-7); Primary Dermal Sensitization; Mammals; Guinea Pigs; Dermal; Toxic substances; Laboratory animals;

机译：毒理学;健康影响;庚醛（111-71-7）;原代皮肤致敏;哺乳动物;豚鼠;皮肤;有毒物质;实验动物;

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Toxicology of Ethylene Oxide Derivatives: the Skin Sensitizing Potential of Heptanal (Final Report) with Attachment and Cover Letter Dated 12/02/1991

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