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首页> 美国政府科技报告 >Some Radiopharmaceuticals Derived from Carbon-Eleven Labelled Phosgene. Synthesis and Clinical Application.
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Some Radiopharmaceuticals Derived from Carbon-Eleven Labelled Phosgene. Synthesis and Clinical Application.

机译：一些放射性药物衍生自碳十一标记的光气。合成与临床应用。

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This thesis deals with some applications of the short lived cyclotron produced radioisotope carbon-11 (half life 20.4 min.) For medical use. Both chemical manipulation of highly radioactive gamma emitting material in order to prepare suitable exp 11 C-labelled radiopharmaceuticals and two clinical studies are discussed. The first chapter comprises a general introduction concerning the application of the ''tracer principle'' to the short lived positron emitting radionuclides exp 18 F, exp 11 C, exp 13 N and exp 15 O in medicine. Chapter two deals with the synthesis of exp 11 COCl sub 2 . This product is a useful new exp 11 C-synthon with many potential applications. In chapter three the synthesis of exp 11 C-urea from exp 11 C-phosgene for medical use is described. The method uses the reaction of exp 11 COCl sub 2 with aqueous ammonia. Chapter four deals with the synthesis of exp 11 C-barbituric acids and exp 11 C-hydantoins and presents a clinical study on epilepsy, using 2- exp 11 C-5,5-diphenylhydantoin ( exp 11 C-DPH). Patients having intractable epilepsy and patients having no epilepsy were given intravenously a single dose of exp 11 C-DPH after which the accumulation of the radioactivity in the brain was followed by positron emission tomography. No regional concentration differences could be found near epileptic foci. There was a faint indication that there are some differences in uptake for whole brain between the two categories of patients. (Atomindex citation 14:717519)

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