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首页> 美国政府科技报告 >Efficient Microscale Preparation of Tin-117M-Tin Tetrachloride-a Pivotal Intermediate for the Synthesis of Tin-117M-Labeled Radiopharmaceuticals
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Efficient Microscale Preparation of Tin-117M-Tin Tetrachloride-a Pivotal Intermediate for the Synthesis of Tin-117M-Labeled Radiopharmaceuticals

机译：高效微量制备锡-117m-四氯化锡 - 一种用于合成Tin-117m标记的放射性药物的关键中间体

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A microscale technique has been developed for the preparation of /sup 117m/SnCl sub 4 . The radiolabeled tin tetrachloride is an important intermediate for the synthesis of /sup 117m/Sn-labeled organic radiopharmaceuticals. The flow-through system involves high temperature chlorination of metallic /sup 117m/Sn with subsequent cryogenic collection of the /sup 117m/SnCl sub 4 in a special reaction vessel. This vessel can then be used for the conversion of the tin tetrachloride to various useful intermediates. The reactions that have been studied include the formation of tetraalkyl and tetraaryltin compounds by reaction of SnCl sub 4 with Grignard or alkyl and aryl lithium reagents (SnCl sub 4 implies R sub 4 Sn or Ar sub 4 Sn). In addition, by stoichiometric control, the comproportionation of SnCl sub 4 with tetramethyltin can yield any one of the mixed methylchlorotin intermediates, MeSnCl sub 3 , Me sub 2 SnCl sub 2 , or Me sub 3 SnCl. These products are important intermediates for the preparation of /sup 117m/Sn-labeled steroids, fatty acids, amino acids, barbituates, and a variety of other potentially useful agents. (ERA citation 04:034392)

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