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Effect of Jaundiced Sera and Bile Salts on Cultured Beating Rat Heart Cells

机译:黄疸血清和胆汁盐对培养大鼠心肌细胞的影响

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Jaundiced serum, from common bile duct ligated rats, added to cultured heart cells decreased the beating rate and caused an early cessation of beating. Similarly it produced higher levels of lactate in the media. Deoxychloic acid but not cholic acid which are the main bile acids in jaundiced serum caused similar effects, thus suggesting that deoxychloic acid is the toxic substance responsible for heart function alterations seen in severe jaundiced patients. (ERA citation 06:012940)

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