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Pulse Radiolysis and Stopped-Flow Studies into the Mechanism of Radiosensitizing Action or Organic Nitro-Compounds. Part of a Coordinated Programme on Improvement in Radiotherapy of Cancer Using Modifiers of Radiosensitivity of Ce

机译：脉冲辐解和停止流动研究放射增敏作用或有机硝基化合物的机制。使用Ce放射敏感性改良剂改善癌症放射治疗的协调计划的一部分

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The formation of long-lived radical-cations on reaction of chlorpromazine with hydroxyl radicals could account for the radiosensitising effect of the drug (Shenoy et al 1975). It may also account for the observed cytotoxic action of the drug on hypoxic cells. An analogous reaction to the observed reaction of the phenothiazine radical cation from promethazine with cysteamine may similarly account for the protective effect of the sulphydryl compounds dithiothreitol or glutathione in these systems. (Shenoy et al, 1978). The reduction in induced mutation frequency when bacteria are incubated with metronidazole and cysteamine indicates that cysteamine may act not only by scavenging short lived toxic species but also by repairing long-lived damage to vital molecules. (Atomindex citation 12:588034)

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作者
Willsin, R.;
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年度 1979
页码 1-11
总页数 11
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Chlorpromazine; Glutathione; Mea; Metronidazole; Anoxia; Biochemical reaction kinetics; Experimental data; Fluid flow; Mutation frequency; Radiolysis; Radiosensitivity; Radiosensitivity effects; Time dependence; Toxicity;

机译：氯丙嗪;谷胱甘肽; mea;甲硝唑;缺氧;生化反应动力学;实验数据;流体流动;突变频率;放射分解;放射敏感性;放射敏感性作用;时间依赖性;毒性;

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1. Radiosensitizing biological modifiers enhancing efficacy in non-small-cell lung cancer treated with radiotherapy [J] . Georg Holgersson, Stefan Bergstrom, Simon Ekman, Lung cancer management. . 2013,第4期

机译：放射增敏生物修饰剂增强放疗治疗非小细胞肺癌的疗效
2. Mechanisms of flavonoid repair reactions with amino acid radicals in models of biological systems: a pulse radiolysis study in micelles and human serum albumin. [J] . Filipe P, Morliere P, Patterson LK, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2002,第2期

机译：在生物系统模型中类黄酮与氨基酸自由基的修复反应机理：对胶束和人血清白蛋白的脉冲放射分解研究。
3. Mechanisms of flavonoid repair reactions with amino acid radicals in models of biological systems: a pulse radiolysis study in micelles and human serum albumin. [J] . Filipe P, Morliere P, Patterson L, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2002,第1期

机译：在生物系统模型中类黄酮与氨基酸自由基的修复反应机理：对胶束和人血清白蛋白的脉冲放射分解研究。
4. Study on radiation-induced reaction in microscopic region for basic understanding of electron beam patterning in lithographic process (I) - development of subpicosecond pulse radiolysis and relation between space resolution and radiation-induced reac [C] . T. Kozawa, A. Saeki, Y. Yoshida, International Microprocesses and Nanotechnology Conference . 2001

机译：微观区域辐射诱导反应的基本理解，用于光刻过程中的电子束图案化（I） - 微脉冲辐射分解的开发和空间分辨率与辐射诱导的Reac之间的关系
5. ELECTRON SPIN RESONANCE AND PULSE RADIOLYSIS STUDIES OF THE MECHANISM AND KINETICS OF THE SULFATE RADICAL ANION REACTIONS WITH AROMATIC COMPOUNDS IN AQUEOUS SOLUTION. [D] . ZEMEL, HAYA. 1977

机译：水溶液中硫酸根离子与阴离子的反应机理和动力学的电子自旋共振和脉冲放射性研究。
6. The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Evidence that only half the active sites function in catalysis [O] . E. Martin Fielden, Peter B. Roberts, Robert C. Bray, 1974

机译：脉冲辐射分解和电子顺磁共振中超氧化物歧化酶的作用机理。仅有一半活性位点在催化中起作用的证据
7. Studies on Reaction Mechanisms of EB Resist by Pulse Radiolysis. [O] . Shou TSUJI, Takahiro KOZAWA, Yukio YAMAMOTO, 2000

机译：脉冲辐射反应的EB抗蚀剂反应机理研究。
8. Mechanism of Action of Shoulder-Modifying Anoxic Radiosensitizers and Their Use in Combination with Other Treatment Modalities. Coordinated Programme on Improvement in Radiotherapy of Cancer Using Modifiers of Radiosensitivity of [R] . Harris, J. W. 1982

机译：肩改良缺氧放射增敏剂的作用机理及其与其他治疗方式的结合使用。利用放射敏感性改良剂改善癌症放射治疗的协调方案

Pulse Radiolysis and Stopped-Flow Studies into the Mechanism of Radiosensitizing Action or Organic Nitro-Compounds. Part of a Coordinated Programme on Improvement in Radiotherapy of Cancer Using Modifiers of Radiosensitivity of Ce

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