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Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994

机译：对活化血小板特异的单克隆抗体（sZ-51）可用于血栓形成的诊断。 1990年12月至1994年4月期间的最后报告

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Non invasive detection and localisation of thrombogenesis in various clinical disorders remains a challenge. Mr. C. Ruan and his co-workers from the Jiangsu Institute of Hematology, Thrombosis and Hemostasis Research Unit, Suzhon Medical College, Suzhon, China, had successfully developed the entire steps from the production, purification and radiolabelling of a monoclonal antibody to an alpha granule protein expressed on the surface of activated platelets, to the validation of its immunoreactivity with activated platelets in few clinical disorders characterised by injury to platelets. Further, they have labelled this monoclonal antibody with 99mTc and demonstrated in vivo localisation of thrombogenic foli by an experimental model in dogs using immunoscintigraphic techniques. Biodistribution studies had clearly shown significant labelled antibody accumulation in thrombogenic foli compared to the surrounding blood and soft tissue background. Radiolabelled monoclonal antibody scintigraphy is thus shown to have potential in achieving the hitherto elusive goal of non invasive localisation of thrombogenesis in clinical practice. (Atomindex citation 26:015865)

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作者
Ruan, C.;
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年度 1994
页码 1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cardiovascular System; Thrombosis; Antigen-Antibody Reactions; Blood Serum; Diagnosis; Diagnostic Techniques; Dogs; Labelled Compounds; Scintiscanning; Technetium; Tracer Techniques;

机译：心血管系统;血栓形成;抗原 - 抗体反应;血清;诊断;诊断技术;犬;标记化合物; scintiscanning;锝;示踪技术;

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专利

1. A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain. [J] . Xu Y, Li J, Fang W, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2009,第2期

机译：基于P-选择素单克隆抗体SZ-51轻链的潜在血栓诊断试剂。
2. A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain. [J] . Xu Y, Li J, Fang W, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2009,第2期

机译：基于p聚蛋白单克隆抗体SZ-51轻链的潜在血栓诊断试剂。
3. The detection of platelet antibodies by simultaneous analysis of specific platelet antibodies and the monoclonal antibody-specific immobilization of platelet antigens: an interlaboratory comparison [J] . Xuan Due Nguyen, Meike Goebel, Michael Schober, Transfusion: The Journal of the American Association of Blood Banks . 2009,第7aPta1期

机译：通过同时分析特异性血小板抗体和血小板抗原的单克隆抗体特异性固定来检测血小板抗体：实验室间比较
4. A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. [O] . B S Coller 1985

机译：一种新的鼠类单克隆抗体报道了血小板糖蛋白IIb / IIIa复合物的构象和/或微环境中的活化依赖性变化。
5. Proposal for a Council Decision on the conclusion of the Agreement in the form of an exchange of lettersconcerning the provisional application of the Protocol on the conditions relating to fishing provided for in the agreement on fisheries between the European Economic Community on the one hand, and the Government of Denmark and the Home Rule Government of Greenland, on the otherhand, for the period from 1 January 1990to 31 December 1994. Proposal for a Council Regulation (EEC)relating to the conclusion of the protocol laying down the conditions relating to fishing provided for in the Agreement on fisheries between the European Economic Community, on the one hand, and the Government of Denmark and the Home RuleGovernment of Greenland on the other (presented by the Commission). COM (89) 617 final, 11 December 1989 [O] . 1989

机译：关于以换文的形式缔结协定的决定的提案关于欧洲经济共同体与丹麦政府和格陵兰自治政府之间渔业协定规定的关于捕捞条件的暂定适用议定书从1990年1月1日起，至1994年12月31日。关于理事会条例（EEC）的提案关于欧洲经济共同体与丹麦政府和本国规则之间关于渔业协定规定的有关捕捞条件的议定书的缔结格陵兰政府另一方（由委员会提交）。 COm（89）617决赛，1989年12月11日
6. Radioimmunoscintigraphy of experimental internal carotid arterial thrombi in dogs with (sup 99m)Tc-labelled monoclonal anti-activated platelet antibody SZ-51 [R] . Bao Shiyao, Li Wen, He Guangren, 1995

机译：用（sup 99m）Tc标记的单克隆抗活化血小板抗体sZ-51对犬实验性颈内动脉血栓的放射免疫显像

Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994

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