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首页> 美国政府科技报告 >A Study of 'Immediate' Sensitization by Adsorption of Antigens and Antibodies in Vitro.
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A Study of 'Immediate' Sensitization by Adsorption of Antigens and Antibodies in Vitro.

机译：体外抗原和抗体吸附“即时”致敏作用的研究。

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The direct cardiotoxicity of streptolysin O (SLO) may be aggravated by an additional hypersensitivity reaction between SLO and specific, tissue-bound antibody. The isolated guinea pig heart responds to purified SLO with a rapid, transient decrease in rate and amplitude of contraction, superimposed on a gradual, irreversible loss of ventricular contractility. At ventricular standstill, the atria beat normally, as do electrically driven strips of the arrested ventricles. Ventricle strips from normal hearts are completely insensitive to the toxin. However, isolated atria respond to SLO with a reversible decrease in rate and amplitude of contraction accompanied by a marked, transient increase in the rate of repolarization of the intracellular potential. All of the transient changes are shown to be due to acetylcholine release by the atria; the permanent ventricular decline results from a toxin-induced defect in atrioventricular conduction. Oxidized (inactive) SLO elicits the production of anaphylactic antibodies in the guinea pig, and when challenged with the oxidized or reduced (active) toxin, whole hearts and isolated atria from these animals respond anaphylactically and release histamine. Serum from rabbits immunized with the oxidized toxin passively sensitizes guinea pig cardiac tissue in vitro. These tissues, when challenged with either form of SLO, react anaphylactically and release histamine. The response of sensitized atria to reduced toxin consists of the depression of the direct toxic effect (acetylcholine), followed by the potentiation of the anaphylactic reaction (histamine). Thus, SLO can participate in multiple reactions with cardiac tissues. (Author)

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