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Synaptonemal Complex Damage Induced by Clastogenic and Anti-Mitotic Chemicals: Implications for Non-Disjunction and Aneuploidy (Journal Version)

机译：致裂和抗有丝分裂化学物质诱导的联合复合物损伤：对非分离和非整倍性的影响（期刊版）

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Mice were treated with mitomycin C, cyclophosphamide, amuscarine, colchicine, or vinblastine sulfate, and meiotic prophase cells analyzed for synaptonemal complex damage. All test agents caused synaptonemal complex breakage and synapsis irregularities, although propensities for inducing specific types of damage at S-phase or prophase stages varied among the chemicals. The data indicate that SC analysis can reveal chemical-specific alterations to meiotic homologue pairing/synapsis which have not generally been recognized, and which theoretically may be implicated in nondisjunction.

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Allen, J. W. ; Gibson, J. B. ; Poorman, P. A. ; Backer, L. C. ; Moses, M. J.;
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年度 1988
页码 1-14
总页数 14
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Mutagens; Toxicology; Synopses; Mice; Laboratory animals; Exposure; Meiosis; Mitomycins; Cyclophosphamide; Colchicine; Chromosome abnormalities; Reprints;

机译：致突变物;毒理学;概要;小鼠;实验室动物;暴露;减数分裂;丝裂霉素;环磷酰胺;秋水仙碱;染色体异常;重印;

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机译：从大麦中提取的β-葡聚糖对鼠类细胞化学诱导的DNA损伤具有抗破伤作用。
2. DNA Damage during Meiosis Induces Chromatin Remodeling and Synaptonemal Complex Disassembly. [J] . Couteau F, Zetka M Developmental cell . 2011,第3期

机译：减数分裂过程中的DNA损伤诱导染色质重塑和突触复合体分解。
3. X-ray-induced synaptonemal complex damage during meiotic prophase in female fetuses of Rattus norvegicus. [J] . Pujol R, Cusido L, Rubio A, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1997,第2期

机译：X射线诱导褐家鼠雌性胎儿减数分裂前期的突触复合体损伤。
4. Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo [C] . S.D. Ray, T.S. Lam, J.A. Rotollo, International Conference on Food Factors . 2004

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5. Oxidative voltammetric electrochemical analysis of chemically induced DNA damage. [D] . Zhou, Liping. 2002

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6. p31comet inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs [O] . Toshiyuki Habu, Tomohiro Matsumoto -1

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7. DNA Damage during Meiosis Induces Chromatin Remodeling and Synaptonemal Complex Disassembly [O] . Couteau Florence, Zetka Monique 2011

机译：减数分裂过程中的DNA损伤诱导染色质重塑和突触复合体拆卸。
8. Detection of Chemically Induced Aneuploidy by the 'Vicia faba' Root Tip Assay (Journal Version) [R] . Acedo, G. N. , Sandhu, S. S. 1988

机译：'蚕豆'根尖测定法检测化学诱导的非整倍体（期刊版）

Synaptonemal Complex Damage Induced by Clastogenic and Anti-Mitotic Chemicals: Implications for Non-Disjunction and Aneuploidy (Journal Version)

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