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首页> 美国政府科技报告 >Screening Test for Neurotoxins Using 'Caenorhabditis elegans'
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Screening Test for Neurotoxins Using 'Caenorhabditis elegans'

机译：使用'秀丽隐杆线虫'筛选神经毒素

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A screening test was proposed for neurotoxins using a computer tracking system and Caenorhabditis elegans, a species of nematode. Simultaneous tracking of several hundred nematodes, recording their rates of locomotion and frequency of direction change were reported in real time. Reliable data on a variety of behavioral parameters relating to locomotion and response to sensory stimulation were obtained. The effects on locomotion caused by copper (7440508), beryllium (7440417), mercury (7439976), lead (7439921), malathion (121755), and vapona (62737) were studied. Copper and beryllium were not known to be neurotoxins. The rate of movement of exposed nematodes compared to the rate of movement of vehicle controls indicated that this test can be used as an indicator of neurotoxicity. Acute lethality studies were also performed with mercuric chloride (7487947), beryllium sulfate (13510491), aluminum nitrate (13473900), cupric chloride (7447394), zinc chloride (7646857), lead nitrate (10099748), cadmium chloride (10108642), and strontium nitrate (10042769). C. elegans was able to predict mammalian acute lethality by generating median lethal dose levels which were comparable to those obtained with the rat and mouse. The cost of this type of test was about 10 percent of the cost involved in using mammalian testing programs.

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