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Metabolic Activation of Organic Extracts from Diesel, Coke Oven, Roofing Tar, and Cigarette Smoke Emissions in the Ames Assay

机译：ames试验中柴油，焦炉，屋顶焦油和卷烟烟气排放的有机提取物的代谢活化

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The role of metabolic activation in the difference between a microbial and mammalian bioassays in the ranking of genotoxic potency of several environmental emissions was investigated. Although the relative potency in the Ames assay correlated well with the relative potency in mammalian cell and mouse skin for a series of automotive emissions (diesel and gasoline) this was not the case for the coke oven, roofing tar and cigarette smoke condensate (CSC) emissions. The study examined several parameters of the metabolic activation with Salmonella typhimurium TA98 including S9 concentration and a comparison of Aroclor-1254 induced with uninduced S9 from both rat and hamster liver. The diesel emissions sample was direct acting while the other samples required activation. The standard S9 concentration (approximately 1.25 mg protein/plate) also produced the maximum mutagenic activity. Induced S9s produced higher mutagenic activity than uninduced. The hamster S9 gave significantly higher mutagenic activies than rat S9 for the coke oven and CSC.

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作者
Williams, K. ; Lewtas, J.;
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年度 1985
页码 1-14
总页数 14
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Bioassay; Toxicology; Air pollution; Emissions; Reprints;

机译：生物测定;毒理学;空气污染;排放;重印;

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1. Organic extracts of coke oven emissions can induce genetic damage in metabolically competent HepG2 cells [J] . Lili Xin, Jianshu Wang, Sifan Guo, Environmental toxicology and pharmacology . 2014,第3期

机译：焦炉排放物的有机提取物可在代谢能力强的HepG2细胞中诱导遗传损伤
2. Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation [J] . MaiY., HigashiT., TeradaK., Journal of pharmacological sciences. . 2012,第4期

机译：不含尼古丁和焦油的香烟烟雾提取物通过细胞内Ca2 +依赖性亚型特异性蛋白激酶C活化诱导细胞损伤
3. Nicotine- and Tar-free Cigarette Smoke Extract Induces Cell Injury via Intracellular Ca2+-Dependent Subtype-Specific Protein Kinase C Activation [J] . Chizuru Hatate, Koji Terada, Mika Horiguchi, Journal of pharmacological sciences. . 2012,第4期

机译：不含尼古丁和焦油的香烟烟雾提取物通过细胞内Ca2 +依赖性亚型特异的蛋白激酶C激活诱导细胞损伤。
4. THE NEURAL NETWORK PREDICTION OF DIESEL ENGINE SMOKE EMISSION FROM ROUTINE ENGINE OPERATING PARAMETERS OF AN OPERATING ROAD VEHICLE [C] . E.Berry, J.Wright, P.Kukla, 14th International Congress on Condition Monitoring and Diagnostic Engineering Management (Comadem 2001), 14th, Sep 4-6, 2001, Manchester, UK . 2001

机译：行驶车辆的常规发动机运行参数对柴油机烟雾排放的神经网络预测
5. THE COLLECTION, SEPARATION, IDENTIFICATION AND QUANTITATION OF SELECTED POLYNUCLEAR AROMATIC HYDROCARBONS AND METALS IN COAL TAR AND COKE-OVEN EMISSIONS. [D] . WHITE, LOWELL D. 1975

机译：在煤焦油和焦炉排放物中选择的多核芳香烃和金属的收集，分离，鉴定和定量。
6. Comparative carcinogenic potencies of particulates from diesel engine exhausts coke oven emissions roofing tar aerosols and cigarette smoke. [O] . R E Albert 1983

机译：柴油机废气焦炉排放物屋顶焦油气雾剂和香烟烟雾中颗粒物的致癌性比较。
7. Comparative carcinogenic potencies of particulates from diesel engine exhausts, coke oven emissions, roofing tar aerosols and cigarette smoke. [O] . Albert, R E 1983

机译：柴油机废气，焦炉排放物，屋顶焦油气雾剂和香烟烟雾中颗粒物的致癌性比较。
8. Mutagenicity of the Fractionated Organic Emissions from Diesel, Cigarette Smoke Condensate, Coke Oven, and Roofing Tar in the Ames Assay [R] . Austin, A. C. , Claxton, L. D. , Lewtas, J. 1985

机译：在ames试验中柴油，香烟烟雾冷凝物，焦炉和屋顶焦油的分馏有机物排放的致突变性

Metabolic Activation of Organic Extracts from Diesel, Coke Oven, Roofing Tar, and Cigarette Smoke Emissions in the Ames Assay

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