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首页> 美国政府科技报告 >Toxicologic Evaluation of Intravenously-Administered Actinomycin D (NSC 3053) in BDF1 Mice
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Toxicologic Evaluation of Intravenously-Administered Actinomycin D (NSC 3053) in BDF1 Mice

机译：静脉注射放线菌素D（NsC 3053）在BDF1小鼠中的毒理学评价

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In BDF1 mice administered a single intravenous dose of actinomycin D, calculated estimates of the LD(90), LD(50), and LD(10) were 1.64, 1.44, and 1.27 mg/kg (4.92, 4.32, and 3.81 mg/sq m), respectively, for males; and 1.72, 1.52, and 1.34 mg/kg (5.16, 4.56, and 4.02 mg/sq m), respectively, for females. Estimates for mice administered five daily doses of actinomycin D were 0.35, 0.32, and 0.29 mg/kg/day (1.05, 0.96, and 0.87 mg/sq m/day) in males and 0.41, 0.37, and 0.33 mg/kg/day (1.23, 1.11, and 0.99 mg/sq m/day) in females. These data suggest that there is no difference in the susceptibility of male and female mice to lethal toxicity following a single dose and five daily doses of actinomycin D. Further comparison of the data suggests that the toxicity of actinomycin D is lower following five daily doses; therefore, the toxicity does not appear to be cumulative. Qualitative toxicity was similar in both sexes following the single-dose and five-daily-dose schedules. Reversible toxicity to the gastrointestinal tract and the hematopoietic and lymphoid systems was observed following both the single-dose and the five-daily-dose schedules. Histopathologically confirmed reversible gastrointestinal toxicosis was characterized clinically by a slight, initial loss of weight followed by a gradual increase in body weight. Slight peripheral anemia and thrombocytopenia were confirmed by microscopic observation of hematopoietic hypoplasia.

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