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首页> 美国政府科技报告 >A Seroepidemiologic Study of Cases of Acute Hepatitis
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A Seroepidemiologic Study of Cases of Acute Hepatitis

机译：急性肝炎病例的血清流行病学研究

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249 patients with sporadic acute viral hepatitis were identified at 5 hospitals in Baltimore over 15 months. Controls were selected from patients without liver disease seen at the same hospitals, matched to the cases by age, sex, and race. Patients were interviewed and serial serum samples collected. 44% of the cases were non-A, non-B (NANB) as defined by the absence of serologic markers (by RIA) of either active hepatitis B infection (HBsAg, IgM anti-HBc) or active hepatitis A infection (IgM-HAV). 46% had hepatitis B; 10% had hepatitis A. Compared to controls, NANB cases more often had parenteral exposures, i.e. blood transfusions (12% v0%, p<.05) and parenteral drug abuse (39% v 6% p<.05), or had personal contact with others who had hepatitis (11% v 2%, p<.05). Of those cases without an obvious source of infection, 20% were health workers, a rate 3 times that of controls. More than half of the NANB infections were a result of parenteral exposure and these cases more often had both seriologic markers indicating previous HBV infection and a previous episode of clinical hepatitis than cases without parenteral exposure. Evidence for other modes of transmission including secondary transmission in families was found, and the remaining individuals with no apparent source for their infection (30%) may have been exposed to asymptomatic cases or chronic carriers.

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