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首页> 美国政府科技报告 >NIOSH (National Institute for Occupational Safety and Health) Testimony on Ethylene Dichloride and 2,4-Diaminoanisole Before the Subcommittee on Oversight and Investigations, House Committee on Interstate and Foreign Commerce, by Edward J. Baier, January 23, 1978
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NIOSH (National Institute for Occupational Safety and Health) Testimony on Ethylene Dichloride and 2,4-Diaminoanisole Before the Subcommittee on Oversight and Investigations, House Committee on Interstate and Foreign Commerce, by Edward J. Baier, January 23, 1978

机译：NIOsH（国家职业安全与健康研究所）关于监督和调查小组委员会的关于乙烯二氯和2,4-二氨基苯甲醚的证词，州际和外国商业委员会，Edward J. Baier，1978年1月23日

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The statement reviewed the role of the National Institute for Occupational Safety and Health (NIOSH) in investigating ethylene-dichloride (107062) (EDC) and 2,4-diaminoanisole (615054) (DA). In 1976 a criteria documents suggested the standard for exposure to EDC be set at 5 parts per million (ppm) based on reports of adverse effects on the nervous system and livers of workers exposed to 10 to 15 ppm EDC. Higher exposure levels were apparently related to cardiac and respiratory system effects. Nursing mothers were advised not to work with EDC as it could be carried in their milk. Subsequently reports were made of excessive tumors occurring in laboratory mice and rats fed EDC for 78 weeks. In January of 1978 NIOSH issued a Current Intelligence Bulletin recommending that DA and its salts be handled as though they were human carcinogens. Two epidemiologic studies have been reported where excessive cancer has been diagnosed among cosmetologists. One study suggested excessive genital cancer and the other suggested excessive cancer in several organ systems. Other reports indicated mutagenic potential in bacterial systems and in the fruit fly. NIOSH recommended that skin exposure be limited and that engineering and work practice controls be made more stringent.

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