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An Artificial Cochlea for the Sensory Deaf: Presurgical Development.

机译：感觉聋的人工耳蜗：术前发展。

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A flexible, intracochlear multimicroelectrode array is being developed for differential electrical stimulation of the cochlear nerve in human sensory deafness. The conductor elements, 0.3use micrometer thick,are formed on both sides of a thin-film plastic substrate using vacuum deposition and photolithographic techniques. In the present configuration,the array consists of 33platinum conductors, 12.7use micrometer wide,each terminating at an electrode surface, 250use micrometer wide. The electrodes are spaced on 700use micrometer centers. Substrates investigated include Mylar, Parylene-C,and FEP and TFE Teflon films, 50to 130use micrometer thick. Of these Mylar was found best for electrode fabrication. Insulation of the arrary is accomplished by dip-coating in Silastic. The electrode tips are exposed by mechanical scribing techniques. Short-term body tolerance studies in guinea pigs show good compatibility with the electrode materials.

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作者
sonn,martin;
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年度 1973
页码 157p*
总页数 157
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
mechanical organs; cochlea; deafness; therapybioinstrumentation; hearing; labyrinth(anatomy); senses; electrodes; microelectronics; stimulation; auditory nerve; physiological psychology;

机译：机械器官;耳蜗;耳聋;治疗生理器官;听觉;迷宫（解剖学）;感官;电极;微电子学;刺激;听觉神经;生理心理学;

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专利

1. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. [J] . Kim WY, Fritzsch B, Serls A, Development . 2001,第3期

机译：由于发育期间内耳感觉神经元的严重丧失，NeuroD-null小鼠失聪。
2. Neuronal cell adhesion molecule (NrCAM) is expressed by sensory cells in the cochlea and is necessary for proper cochlear innervation and sensory domain patterning during development [J] . Harley Randall J., Murdy Joseph P., Wang Zhirong, Developmental dynamics: an official publication of the American Association of Anatomists . 2018,第7期

机译：神经元细胞粘附分子（NRCAM）由耳蜗中的感觉细胞表达，并且在开发期间适当的耳蜗内接管和感官域图案化是必要的
3. Usher syndrome and non-syndromic deafness: Functions of different whirlin isoforms in the cochlea, vestibular organs, and retina [J] . Mathur Pranav Dinesh, Yang Jun Hearing Research: An International Journal . 2019,第期

机译：亚瑟综合征和非综合征耳聋：耳蜗，前庭器官和视网膜中不同旋转旋转同种型的功能
4. Optical stimulation of the hearing and deaf cochlea under thermal and stress confinement condition [C] . M. Schultz, P. Baumhoff, N. Kallweit, Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics . 2014

机译：在热和压力限制条件下对听觉和耳聋耳蜗的光刺激
5. ACOUSTIC AND ELECTRIC STIMULATION OF THE COCHLEAS OF HEARING AND DEAF GUINEA PIGS AND ELECTROCORTICAL RESPONSES. [D] . TALLEY, JAMES NORRIS. 1970

机译：听觉和聋哑豚鼠耳蜗的电声刺激和电反应。
6. Neuronal Cell Adhesion Molecule (NrCAM) is Expressed by Sensory Cells in the Cochlea and is Necessary for Proper Cochlear Innervation and Sensory Domain Patterning During Development [O] . Randall J. Harley, Joseph P. Murdy, Zhirong Wang, -1

机译：神经元粘附分子（NrCAM）由耳蜗中的感觉细胞表达并且是发育过程中正确进行耳蜗神经支配和感觉域构图的必要条件
7. Changes in speech receptivity of child of congenital deafness having artificial cochlea. [O] . YOKO KITANO 1996

机译：先天性耳聋具有人工耳蜗的孩子的变化。

An Artificial Cochlea for the Sensory Deaf: Presurgical Development.

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