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首页> 美国政府科技报告 >Preclinical Toxicological Evaluation of Intramuscular Administration of 7Beta Methyl Testosterone Propionate (NSC-136 020E) in Dogs,Rats and Rabbits.
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Preclinical Toxicological Evaluation of Intramuscular Administration of 7Beta Methyl Testosterone Propionate (NSC-136 020E) in Dogs,Rats and Rabbits.

机译：在犬，大鼠和家兔中肌内注射7Beta甲基丙酸睾酮（NsC-136 020E）的临床前毒理学评价。

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A preclinical pharmacological evaluation of 7Beta Methyl Testosterone Propionate (100mg/ml in 90% sesame oil and 10% benzyl alcohol) was performed with dogs,rats and rabbits. Groups of 4dogs injected IM with consecutive daily doses of 50, 25mg/kg or with the control vehicle (0.5cc/kg) responded with focal myositis,fibrosis,degeneration of myofibers,necrosis,edema,subacute inflammation and hemorrhage at injection sites and with hyperplasia and accumulation of fat globules in regional lymph nodes. Two drug treated female dogs,sacrificed immediately after the last treatment,also showed hyperplasia of the mammary gland ducts and of the endometrium of the uterus. Rabbits treated with 83.0mg/kg for 5consecutive days and tested on day 6,exhibited elevated BSP retention in 2/6animals;however,no significant histopathology on day 10. Groups of 10rats treated with a single dose of 1000, 320and 100mg/kg IM showed no adverse clinical side effects. In females treated with 1000or 320mg/kg,food intake and body weight gain was significantly greater (p<0.01) than in non-treated females. Thus,treatment produces androgenic effects in female dogs,slight hepatotoxicity in rabbits and increased body weight gain in female rats. All of these effects are compatible with a drug having androgenic activity.

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