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Research and Development on Human Histocompatibility and Transplantation Immunology

机译：人体组织相容性和移植免疫学的研究进展

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294 Sera from women during pregnancy were tested with 20 different lymphocyte suspensions; 26 sera showed one or more strongly positive reactions. The results obtained so far with absorptions of 13 sera are given in detail. Studies regarding differences in cell specificity of cytotoxic-, agglutinating- and incomplete leucocyte antibodies were performed. The results confirmed the earlier described finding of three types of iso-antigens as well as the fact that only the antigens common to lymphocytes and granulocytes are demonstrable of skin fibroblasts of the same donor. Evidence was found that human lymphocytes and fibroblasts derived from human skin, sensitized by complement fixing iso-antibodies and complement, adhere to the surface of indicator cells. The reaction mechanism showed the characteristics of the immune adherence phenomenon. Experiments made clear that in the immune adherence assay the same antibody is detected as in the cytotoxic antibody test based on dye exclusion. Immune adherence of lymphocytes sensitized by complement fixing isoantibodies and complement, to the surface of granulocytes gives rise to the formation of mixed granulocyte-lymphocyte agglutination. Therefore, a positive result in the leucoagglutination test with leucocytes from defibrinated blood may be caused by the presence of two different types of antibody: true leucoagglutinins and cytotoxic leucocyte antibodies. (Author)

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