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首页> 美国政府科技报告 >Production, Standardization and Packaging of Seed Viruses and 'Monotypic' Mouse Ascites Fluid and Serum Antibodies for 3 Arboviruses
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Production, Standardization and Packaging of Seed Viruses and 'Monotypic' Mouse Ascites Fluid and Serum Antibodies for 3 Arboviruses

机译：用于3种虫媒病毒的种子病毒和'monotypic'小鼠腹水液和血清抗体的生产，标准化和包装

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The re-formed agent pool of Turlock virus deemed type-specific from the results of the tests and found free of adventitious microorganisms and several murine viruses was used to prepare 15 subpools (total 6,700 ml) of immune ascitic fluid and 6 subpools (total 490 ml) of immune serum in mice. All ascitic fluid and serum subpools were tested for homologous and heterologous (California and SSF) titers and found type-specific; they are free of bacteria, fungi and PPLO. Two miniature pools representing proportional samples of immune ascitic fluid subpools and of immune serum subpools were tested for potency (SDE/LD50 and neutralization index), purity (absence of antibodies to murine viruses) and safety (absence of live virus). Results were satisfactory. Treatment of immune ascitic fluids and sera with beta-propiolactone did not affect antibody titer; it seems useful in the elimination of low-level contamination of such reagents with adventitious viruses. (Author)

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