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Stilbene Derivatives and Their Use for Binding and Imaging Amyloid Plaques.

机译：二苯乙烯衍生物及其用于结合和成像淀粉样斑块的用途。

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摘要

This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

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作者
Kung, H. F.; Kung, M. P.; Zhuang, Z. P.;
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年度 2005
页码 1-30
总页数 30
原文格式 PDF
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关键词
Amyloid; Patent applications; Amyloidosis; Proteins; Chemical compounds; Aggregation; Imaging techniques; Therapy; Amyloid plaques; Amyloid deposits;

机译：淀粉样蛋白;专利申请;淀粉样变性;蛋白质;化学化合物;聚集;成像技术;治疗;淀粉样斑块;淀粉样沉积物;

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专利

1. Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques. [J] . Hong MC, Kim YK, Choi JY, Bioorganic and medicinal chemistry . 2010,第22期

机译：二苯乙烯衍生物作为淀粉样斑块的潜在成像剂的合成和评估。
2. 99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for beta-amyloid plaques. [J] . Cui M, Tang R, Li Z, Bioorganic and Medicinal Chemistry Letters . 2011,第3期

机译：99mTc-和重新标记的6-二烷基氨基-2-萘乙叉衍生物作为β-淀粉样蛋白斑的成像探针。
3. Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques. [J] . Swahn BM, Wensbo D, Sandell J, Bioorganic and Medicinal Chemistry Letters . 2010,第6期

机译：将2-吡啶基苯噻唑，2-吡啶基苯并恶唑和2-吡啶基苯脲衍生物作为β-淀粉样蛋白斑块的11C-PET成像剂的合成与评价。
4. Insights on the Binding of Thioflavin Derivative Markers to Amyloid Fibril Models and Aβ_(1-40) Fibrilsfrom Computational Approaches [C] . Jorge Ali-Torres, Albert Rimola, Cristina Rodriguez-Rodriguez, International conference on computational methods in science and engineering 2014 . 2014

机译：硫黄素衍生物与淀粉样纤维模型和Aβ_（1-40）纤维的结合从计算方法的见解。
5. In vivo molecular imaging probes for Alzheimer's disease: Molecular requirements for binding of 2-[1-(6-dialkylamino-2-naphthyl)ethylidene]malononitrile molecular imaging probes to beta-amyloid fibrils and senile plaques. [D] . Agdeppa, Eric Dustin. 2002

机译：阿尔茨海默氏病的体内分子成像探针：2- [1-（6-二烷基氨基-2-萘基）亚乙基]丙二腈分子成像探针与β-淀粉样蛋白原纤维和老年斑结合的分子要求。
6. Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species [O] . Joseph J. Braymer, Jung-Suk Choi, Alaina S. DeToma, -1

机译：用于定位和调制金属β淀粉样种双功能二苯乙烯衍生物的开发
7. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. [O] . Christian T Farrar, Christopher M William, Eloise Hudry, 2014

机译：RNa适体探针作为用于检测淀粉样斑块的光学成像剂。

Stilbene Derivatives and Their Use for Binding and Imaging Amyloid Plaques.

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