Compositions and Methods for Modification of Biomolecules.

机译：用于改性生物分子的组合物和方法。

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The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

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Bertozzi, C. R.; Agard, N. J.; Prescher, J. A.; Baskin, J. M.;
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年度 2005
页码 1-35
总页数 35
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Patent applications; Biomolecules; Molecular biology; In vivo; In vitro; Modification; Compositions; Methods; Modified cycloalkyne compounds; Cycloaddition reactions; Covalently modified biomolecules;

机译：专利申请;生物分子;分子生物学;体内;体外;修饰;组合物;方法;修饰的环炔化合物;环加成反应;共价修饰的生物分子;

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Compositions and Methods for Modification of Biomolecules.

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