首页> 美国政府科技报告 >Support: Letter from Methacrylate Producers to USEPA with Additional Information re: an Acute Inhalation Toxicity Study of Ethyl and Methyl Methacrylate in Rats (8EHQ-0401-14894), as Requested by USEPA, dated 10/11/2001
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Support: Letter from Methacrylate Producers to USEPA with Additional Information re: an Acute Inhalation Toxicity Study of Ethyl and Methyl Methacrylate in Rats (8EHQ-0401-14894), as Requested by USEPA, dated 10/11/2001

机译:支持:甲基丙烯酸酯生产商致美国环保局的补充信息:大鼠乙基和甲基丙烯酸甲酯的急性吸入毒性研究(8EHQ-0401-14894),美国环保局要求,日期为10/11/2001

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The study was conducted with 5 male F344 rats with bodyweights between 265-295 grams. The rats were exposed to 200 ppm of ethyl methacrylate for a period of 6 hours. The rat: were killed immediately after exposure with halothane and the heads processed exactly as described for methyl methacrylate in previous studies. The nasal tissue of rats exposed to ethyl methacrylate showed slight to moderate degeneration of the olfactory epithelium lining the central septum and mid ethmo-turbinates. The effects were similar in appearance and distribution to those observed for methyl methacrylate (CAS No. 80-62-6). The respiratory mucosa throughout the nasal passages and the olfactory mucosa in regions adjacent to these areas were not affected by exposure to ethyl methacrylate. These data were presented at the last SOT meeting and the Abstract is attached.

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