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Continuous Twice Daily or Once Daily Amoxicillin Prophylaxis Compared to Placebofor Children with Recurrent Otitis Media. Abstract, Executive Summary and Tables 1-4

机译:每日连续两次或每日一次阿莫西林预防与复发性中耳炎的placebofor儿童相比。摘要,执行摘要和表1-4

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摘要

Objective: To determine the effectiveness of amoxicillin administeredcontinuously twice daily versus once daily versus placebo to prevent new episodes of acute otitis media (AOM). Design: Randomized double blind clinical trial. Setting: A hospital based general pediatric clinic and a private pediatric practice, both in Denver, Colorado. Participants: 194 Children (Age 3 months through 6 years) were enrolled with 3 documented AOM episodes within the prior 6 months, without ventilating tubes or associated anatomic defects, immunodeficiency disorders or allergy to penicillin. Thirty-six were noncompliant and were dropped from the study, leaving 158 evaluable subjects.

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