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首页> 美国政府科技报告 >Relationship between Acute Ozone Responsiveness and the Chronic Loss of Lung211 Function in Residents Exposed to Recurrent Oxidant Air Pollution
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Relationship between Acute Ozone Responsiveness and the Chronic Loss of Lung211 Function in Residents Exposed to Recurrent Oxidant Air Pollution

机译：复发性氧化空气污染对居民急性臭氧反应性与慢性肺功能损失的关系

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The investigators tested the hypothesis that persons with acute respiratory211u001eresponsiveness to ozone are at high risk of chronic lung injury from repeated 211u001eexposure to oxidant air pollution. Nonsmoking, chronically oxidant-exposed adult 211u001eresidents (n=64) underwent lung function measurements during 1986-87 (time 3) a 211u001efollow up of larger scale field studies in 1977-78 (time 1) and 1982-83 (time 2). 211u001eThese 164 subjects showed a large decrease in forced expired volume in one second 211u001e(FEV1) between time 1 and time 2. They did not show continued decline in lung 211u001efunction between time 2 and time 3. Forty-five members of the time 3 group were 211u001estudied in the laboratory in 1989 (time 4) and showed statistically significant 211u001ebut mild acute reductions in FEV1 and forced vital capacity (FVC) during 2-hour 211u001econtrolled chamber exposures to 0.4 ppm ozone. Lung function responses to acute 211u001eozone exposures at time 4 correlated poorly with longer-term FEV1 or FVC changes 211u001eas measured over the previous time intervals (times 1-3). These results don't 211u001esupport the hypothesis that acute lung function responses to ozone exposure can 211u001epredict chronic effects in adult nonsmokers residing in oxidant-polluted 211u001ecommunities, or that such people experience unusually rapid long-term lung 211u001efunction decline.

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