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Effects of Ozone Inhalation on Fibroblast Activation in the Lung: PossibleRelationship to Long-Term Fibrotic Lung

机译：臭氧吸入对肺成纤维细胞活化的影响：与长期纤维化肺癌关系的可能性

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The objectives of this study were to determine if the bronchoalveolar lavage(BAL) of human subjects exposed to ozone exhibited: (1) increased fibroblast stimulating activity (FSA) and/or (2) elevated levels of transforming growth factors (TGFbeta1 and TGFbeta2), proteins implicated as mediators of fibrosis in a variety of organ systems, including the lung. Human subjects were exposed to filtered-air and ozone (0.4 ppm) for 3-hr while performing intermittent, moderate exercise. It was concluded that exposure to ozone did not increase FSA in samples of airway and alveolar lining fluid, but ozone exposure may be associated with increased levels of TGFbeta, a cytokine implicated in the pathogenesis of lung fibrosis.

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作者
Boushey, H.; Fahy, J.; Turck, C.;
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年度 1994
页码 p.1-28
总页数 28
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Ozone; Air pollution effects(Human); Lung; Pulmonary fibrosis; Environmentalhealth; Fibroblasts; Activation; Transforming growth factor beta; Bronchoalveodar lavage fluid; Exposure; Pathology; Fibrosis; Respiratory diseases; Messenger-RNA;

机译：臭氧;空气污染影响（人体）;肺;肺纤维化;环境健康;成纤维细胞;激活;转化生长因子β;支气管肺泡灌洗液;暴露;病理学;纤维化;呼吸系统疾病;信使RNa;

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1. Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts [J] . BorowskiA., KuepperM., HornU., Clinical and experimental allergy : . 2008,第4期

机译：白介素13在肺上皮细胞中发挥凋亡效应，并诱导肺成纤维细胞中促纤维化基因表达
2. THE EFFECTS OF TGF-B AND IL-33 ON THE PRO-FIBROTIC ACTIVITY OF PRIMARY HUMAN LUNG FIBROBLASTS DURING THE DEVELOPMENT OF IPF [J] . Stephenson K. E., Overed-Sayer C. L., John A. E., Thorax: The Journal of the British Thoracic Society . 2017,第Suppla3期

机译：TGF-B和IL-33对IPF发育过程中原发性人肺成纤维细胞促纤维化活性的影响
3. THE EFFECTS OF TGF-B AND IL-33 ON THE PRO-FIBROTIC ACTIVITY OF PRIMARY HUMAN LUNG FIBROBLASTS DURING THE DEVELOPMENT OF IPF [J] . Stephenson K. E., Overed-Sayer C. L., John A. E., Thorax: The Journal of the British Thoracic Society . 2017,第Suppla3期

机译：TGF-B和IL-33对IPF发育过程中原发性人肺成纤维细胞促纤维化活性的影响
4. Effects of Lipid Mediators on the Activation of Human Lung Fibroblasts [C] . S. Takafuji, S. Kuboshima, A. Ishida, Collegium Internationale Allergologicum . 2007

机译：脂质介质对人肺成纤维细胞活化的影响
5. Mechanisms regulating macrophage production of inflammatory mediators in the lung following ozone inhalation: Role of inflammatory mediators in toxicity. [D] . Fakhrzadeh, Ladan. 2002

机译：臭氧吸入后调节肺中炎性介质巨噬细胞产生的机制：炎性介质在毒性中的作用。
6. A Novel Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling [O] . Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, 2020

机译：一种新型的Pan-PDE抑制剂通过抑制TGF-β信号和激活cAMP / PKA信号在人肺成纤维细胞中发挥抗纤维化作用
7. Identification of the Molecular Basis of Anti-fibrotic Effects of Soluble Guanylate Cyclase Activator Using the Human Lung Fibroblast Phosphoproteome [O] . Sunhwa Kim, Ashmita Saigal, Weilong Zhao, 2020

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8. Circulating Factors that Modify Lung Cell DNA Synthesis Following Exposure to Inhaled Oxidants. 1. Effect of Serum and Lavage on Lung Fibroblasts Following Exposure of Adult Rats to 1 ppm Ozone [R] . Tanswell, A. K., Fraher, L. J., Grose, E. C. 1989

机译：暴露于吸入氧化剂后改变肺细胞DNa合成的循环因子。 1.成年大鼠暴露于1ppm臭氧后血清和灌洗对肺成纤维细胞的影响

Effects of Ozone Inhalation on Fibroblast Activation in the Lung: PossibleRelationship to Long-Term Fibrotic Lung

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