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Evaluation of Efficacy of Fecal Occult Blood Testing. Executive Summary ofDissertation

机译：粪便潜血试验效果评价。论文摘要

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摘要

In a case-control study to evaluate the ability of fecal occult blood testing(FOBT) to reduce deaths from colorectal cancer, cases (n=236) were members of a health maintenance organization (HMO) who died of colorectal cancer in 1986-1991. Controls were persons who did not die of colorectal cancer, randomly selected from the HMO membership (n=457). Although a 30% reduction in colorectal cancer mortality was observed for persons who received FOBT sometime in the past relative to persons who never received FOBT, the authors observed little case-control difference for screening that occurred within 3 years before diagnosis, the maximum period of time during which most tumors would be detectable via FOBT. A suggestion of benefit was observed for home but not for office testing, and in individuals less than 75 years but not in those age 75 or older. The modest reduced risk associated with FOBT in these settings/persons may reflect genuine benefit, but the reduced risk associated with FOBT received in the past, well before a tumor might bleed enought to allow detection, may be due to bias. Thus, the authors' results should be interpreted with considerable caution.

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