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Copper-catalyzed synthesis of primary arylamines via cascade reactions of aryl halides with amidine hydrochlorides

机译：铜通过芳基卤化物与am盐酸盐的级联反应催化合成芳基伯胺

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We have developed an efficient method for the synthesis of primary arylamines from aryl halides using amidine hydrochlorides as the ammonia surrogates. The protocol uses 10 mol % CuI as the catalyst, 20 mol % L-proline as the ligand, CS(2)CO(3) as the base, and DMF as the solvent and proceeds the sequential coupling of aryl halides with amidine hydrochlorides and hydrolysis of intermediates to give the target products. This is a convenient, inexpensive, and practical approach to primary arylamines.

机译：我们已经开发了一种有效的方法，可以使用am盐酸盐作为氨代用品从芳基卤化物合成伯芳基胺。该协议使用10 mol％的CuI作为催化剂，20 mol％的L-脯氨酸作为配体，CS（2）CO（3）作为碱，DMF作为溶剂，并进行芳基卤化物与am盐酸盐的顺序偶联水解中间体，得到目标产物。这是伯芳基胺的方便，廉价且实用的方法。

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Gao X. T.; Fu H.; Qiao R. Z.; Jiang Y. Y.; Zhao Y. F.; 赵玉芬;
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年度 2008
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专利

1. Copper-catalyzed synthesis of primary arylamines via cascade reactions of aryl halides with amidine hydrochlorides [J] . Gao XT, Fu H, Qiao RZ, The Journal of Organic Chemistry . 2008,第17期

机译：铜通过芳基卤化物与am盐酸盐的级联反应合成伯芳基伯胺
2. Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides [J] . Yang DS, Fu H, Hu LM, The Journal of Organic Chemistry . 2008,第19期

机译：邻卤代乙酰苯胺衍生物与am盐酸盐的级联反应铜催化合成苯并咪唑
3. Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide [J] . Chuan-Zhou Tao, Juan Li, Yao Fu Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2008,第1期

机译：铜催化从芳基卤化物和2,2,2-三氟乙酰胺合成伯芳基胺
4. Copper-Catalyzed Coupling Reactions of Aryl Halides and Phenols by 4,4’-Dimethoxy-2,2’-bipyridine and 4,7-dimethoxy-1,10-phenanthroline [C] . Yingying Zhao, Xiangyong Wang, Koichi Kodama 日本化学会春季年会講演予稿集 . 2018

机译：芳基卤化物和酚的铜催化偶联反应4,4'-二甲氧基-2,2'-Bi吡啶和4,7-二甲氧基-1,10-菲咯啉
5. Mechanism of the palladium-catalyzed amination of aryl halides: Kinetic studies of the oxidative addition of aryl halides and sulfonates to phosphine complexes of Pd(0) and of the catalytic reaction of amines with aryl halides and base. [D] . Alcazar-Roman, Luis Manuel. 2001

机译：钯催化芳基卤化物胺化的机理：动力学研究氧化芳基卤化物和磺酸盐到Pd（0）的膦配合物中，以及胺与芳基卤化物和碱的催化反应。
6. The Design of a Photoredox Catalyst that Enables the Direct Synthesis of Carbamate-Protected Primary Amines via Photoinduced Copper-Catalyzed N-Alkylation Reactions of Unactivated Secondary Halides [O] . Jun Myun Ahn, Jonas C. Peters, Gregory C. Fu -1

机译：能够通过未活化的二级卤化物的光诱导的铜催化的N烷基化反应直接合成氨基甲酸酯保护的伯胺的光氧化还原催化剂的设计
7. Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides [O] . Yang D. S., Fu H., Hu L. M., 2008

机译：铜通过邻卤代乙酰苯胺衍生物与am盐酸盐的级联反应催化合成苯并咪唑

Copper-catalyzed synthesis of primary arylamines via cascade reactions of aryl halides with amidine hydrochlorides

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