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Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after onset of juvenile idiopathic arthritis (JIA)

机译：幼年特发性关节炎（JIA）发病八年后评估抗II型胶原蛋白抗体，抗CCP，IgA RF和IgM RF与关节损伤有关

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Background: Early appearance of antibodies specific for native human type II collagen (anti-CII) characterizes anearly inflammatory and destructive phenotype in adults with rheumatoid arthritis (RA). The objective of this studywas to investigate the occurrence of anti-CII, IgM RF, IgA RF and anti-CCP in serum samples obtained early afterdiagnosis, and to relate the occurrence of autoantibodies to outcome after eight years of disease in children withjuvenile idiopathic arthritis (JIA).Methods: The Nordic JIA database prospectively included JIA patients followed for eight years with data on remissionand joint damage. From this database, serum samples collected from 192 patients, at a median of four months afterdisease onset, were analysed for IgG anti-CII, IgM RF, IgA RF and IgG anti-CCP. Joint damage was assessed based onJuvenile Arthritis Damage Index for Articular damage (JADI-A), a validated clinical instrument for joint damage.Results: Elevated serum levels of anti-CII occurred in 3.1%, IgM RF in 3.6%, IgA RF in 3.1% and anti-CCP in 2.6% of thepatients. Occurrence of RF and anti-CCP did to some extent overlap, but rarely with anti-CII. The polyarticular andoligoarticular extended categories were overrepresented in patients with two or more autoantibodies. Anti-CII occurredin younger children, usually without overlap with the other autoantibodies and was associated with high levels ofC-reactive protein (CRP) early in the disease course. All four autoantibodies were significantly associated with jointdamage, but not with active disease at the eight-year follow up.Conclusions: Anti-CII, anti-CCP, IgA RF and IgM RF detected early in the disease course predicted joint damage whenassessed after eight years of disease. The role of anti-CII in JIA should be further studied.Keywords: Arthritis, Juvenile Idiopathic Arthritis, Anti-CCP, Rheumatoid factor, Anti-collagen type II antibodies,Child, Joints
机译：背景：对人类天然II型胶原蛋白（抗CII）具有特异性的抗体的早期出现表征了类风湿关节炎（RA）成人的早期发炎和破坏性表型。这项研究的目的是调查在早期诊断后获得的血清样本中抗CII，IgM RF，IgA RF和抗CCP的发生情况，并将自身抗体的发生与儿童特发性关节炎患病八年后的预后相关（方法：北欧JIA数据库前瞻性地纳入了随访了8年的JIA患者，并提供了缓解和关节损伤的数据。从该数据库中，在发病后四个月的中位数，对从192名患者收集的血清样本进行了IgG抗CII，IgM RF，IgA RF和IgG抗CCP分析。关节损伤根据关节损伤的经过验证的临床关节炎少年关节炎损伤指数（JADI-A）进行评估。结果：抗CII的血清水平升高了3.1％，IgM RF升高了3.6％，IgA RF升高了3.1 ％和抗CCP的患者占2.6％。 RF和抗CCP的发生在一定程度上确实有重叠，但很少与抗CII重叠。具有两个或多个自身抗体的患者中多关节和寡关节扩展类别过多。抗CII发生在年幼的儿童中，通常与其他自身抗体没有重叠，并且在疾病过程的早期与高水平的C反应蛋白（CRP）相关。在八年的随访中，所有四种自身抗体均与关节损伤显着相关，但与活动性疾病无关。结论：在疾病过程中早期检测到的抗CII，抗CCP，IgA RF和IgM RF预测八年后评估关节损伤。疾病关键词：关节炎，少年特发性关节炎，抗CCP，类风湿因子，抗胶原II型抗体，儿童，关节

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