• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population
【2h】

Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

机译：谷胱甘肽（GSH-）相关基因中的遗传多态性影响血浆HG /全血HG分配，从鱼类群中收集的血浆中无机和甲基汞水平之间的分布

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10±4.2 and 37±21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3±2.9, 5.8±2.3 µg/L, and 0.33±0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P<0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β=0.22, P=0.035; MeHgP β=0.30, P=0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β=0.59, P=0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
机译：本研究旨在评估多态性在谷胱甘肽（GSTM1，GSTT1，GSTP1，GCLM和GCLM）中的影响，在暴露于甲基汞（MeHG）的人中血液隔室的分布中。从鱼类消费中接触到Mehg的受试者（n = 88）被纳入研究。等离子体隔室中的Hg物种由LC-ICP-MS测定，而基因分型通过PCR测定进行。平均血浆（THGP）和全血（THGB）的总Hg水平为10±4.2和37±21，而平均血浆ehg（mehgp），无机Hg（Ihgp）和Hgp / hgb的平均值为4.3±2.9,5.8 ±2.3μg/ L，分别为0.33±0.15。 GSTM1和GCLC多态性影响THGP和MEHGP（多变量分析，P <0.050）。与GSTM1的受试者相比，GSTM1的Null Homozygotes显示出更高的THGP和MEHGP水平（THGPβ= 0.22，P = 0.035; MEHGPβ= 0.30，P = 0.050）和携带至少一个T等位基因的GCLC具有显着的MEHGP（β = 0.59，p = 0.046）。此外，多晶态GCLM受试者的THGP / THGB比具有非雄性基因型的那些。在一起，本研究的数据表明，通过改变汞种IIN血浆隔室和HGP / HGB分配的汞型分布，GSH相关多态性可能会改变MEHG的新陈代谢。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号