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首页> 外文期刊>BioMed research international >Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population
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Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

机译：谷胱甘肽（GSH-）相关基因的遗传多态性影响食鱼人群血浆血浆Hg /全血Hg的分配以及血浆中无机汞和甲基汞水平的分布

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This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 mug/L, and 0.33 ±0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP beta = 0.22, P = 0.035; MeHgP beta = 0.30, P = 0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (beta = 0.59, P = 0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
机译：这项研究旨在评估谷胱甘肽（GSH-）相关基因（GSTM1，GSTT1，GSTP1，GCLM和GCLC）中多态性对暴露于甲基汞（MeHg）的人血室中Hg分布的影响。研究对象（n = 88）因食用鱼类而接触到甲基汞。血浆区室中的汞种类通过LC-ICP-MS确定，而基因分型则通过PCR分析进行。血浆（THgP）和全血（THgB）的平均总Hg水平为10±4.2和37±21，而血浆MeHg（MeHgP），无机Hg（IHgP）和HgP / HgB的平均水平为4.3±2.9、5.8分别为±2.3杯/升和0.33±0.15。 GSTM1和GCLC多态性影响THgP和MeHgP（多元分析，P <0.050）。与具有GSTM1的受试者相比，GSTM1的纯合子显示更高的THgP和MeHgP水平（THgP beta = 0.22，P = 0.035; MeHgP beta = 0.30，P = 0.050），携带至少一个T等位基因用于GCLC的人的MeHgP（beta = 0.59，P = 0.046）。同样，多态GCLM受试者的THgP / THgB低于非变异基因型的受试者。两者合计，这项研究的数据表明，与GSH相关的多态性可能会通过改变血浆区室中汞物种的分布和HgP / HgB的分配来改变MeHg的代谢。

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