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首页> 外文OA文献 >Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata and Citrobacter freundii isolated from poultry in South Western Nigeria
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Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata and Citrobacter freundii isolated from poultry in South Western Nigeria

机译：尼日利亚州西南部患有肺炎群岛菌株，Morganella Morganii，Leclercia Adecarboxylata和柑橘菌的血糖抑制基因喹硫胺喹啉抗药性

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A serious concern is arising on the coexistence of extended-spectrum beta-lactamase (ESBL) and plasmid mediated quinolone resistance (PMQR) producing bacteria in animal husbandry, which could be transferred to humans, especially in strains that may not be routinely screened for resistance. This study therefore tested the prevalence of ESBL and PMQR genes in selected bacteria isolated from poultry faeces. Faecal droppings of birds were collected from 11 farms in five states in South Western Nigeria. Bacteria were isolated from the samples on cefotaxime supplemented plates and identified with MALDI-TOF. The MIC was determined using VITEK system and resistance genes were detected with PCR. A total of 350 strains were isolated from different samples and selected strains were identified as 23 Klebsiella pneumonia, 12 Morganella morganii, seven Leclercia adecarboxylata and one Citrobacter freundii. All the species were resistant to gentamycin, trimethoprim/sulphamethaxole, tobramycin, piperacillin, cefotaxime and aztreonam (except Morganella morganii strains which were mostly susceptible to aztreonam). All the tested strains were susceptible to imipenem, meropenem and amikacin. All Leclercia adecarboxylata strains were resistant to ceftazidime, cefepime and fosfomycin while all Morganella morganii strains were resistant to fosfomycin, moxifloxacin and ciprofloxacin. All tested species were generally sensitive to ciprofloxacin except Morganella morganii strains which were resistant to ciprofloxacin. The resistance to ciprofloxacin, ceftazidime, cefepime, tigercylin, colistin and fosfomycin were 65%, 40%, 23%,, 7%, 33%, 48% respectively while the prevalence of SHV, TEM and CTX genes were 42%, 63%, 35% respectively. 9.3% of the isolates had the three ESBL genes, 2.33% had qnrA gene, 4.65% had qnr B gene while none had qnrS gene. The most prevalent PMQR gene is Oqxb (25.58%) while 6.98% had the qep gene. Klebsiella pneumoniae generally had both ESBL and PMQR genes. The high prevalence of extended spectrum beta-lactamase genes in the studied strains calls for caution in the use of beta lactam antibiotics in poultry feeds. This is the first report of the occurrence of extended spectrum beta-lactamase and plasmid mediated quinolone resistance genes in Morganella morganii and Leclercia adecarboxylata strains isolated from poultry faeces.
机译：对畜牧业的扩展光谱β-内酰胺酶（ESBL）和质粒介导的喹啉酮抗性（PMQR）的共存产生严重关注，这些畜牧业的细菌可以转移到人类，特别是在可能不常规筛选的菌株中。因此，该研究测试了从家禽粪便中分离的选定细菌中ESBL和PMQR基因的患病率。在尼日利亚西南部的五个州的11个农场收集了鸟类的粪便粪便。将细菌与小肠补充板上的样品中分离出来并用MALDI-TOF鉴定。使用Vitek系统测定MIC，用PCR检测抗性基因。从不同的样品中分离出350个菌株，并将选定的菌株鉴定为23克尔布拉菌，12摩尔加利亚Morganii，七个leclercia adecarboxylata和一个柠檬酸杆菌。所有物种均对庆大霉素，甲苯甲苄里林/磺胺酰甲脂，染发蛋白，哌啶，头孢噻肟和阿兹特瓜兰（Morganella Morganii菌株除外）大多易于Aztronam）。所有测试的菌株均易于Imipenem，Meropenem和Amikacin。所有Leclercia Adecarboxylata菌株抵抗头孢他啶，头孢噻肟和福孢菌素，而所有Morganella Morganii菌株抵抗氟哌霉素，莫西霉素和环丙沙星。除了莫加勒拉Morganii菌株外，所有测试物种通常对环丙沙星除了耐氧化环氧氟沙星之外。对环丙沙星，头孢唑胺，头孢噻肟，降钙素，Colistin和福染霉素的抗性分别为65％，40％，23％，7％，33％，48％，而Shv，TEM和CTX基因的患病率分别为42％，63％ ，35％。 9.3％的分离物具有三个ESBL基因，2.33％具有QNRA基因，4.65％有QNR B基因，而没有QNR基因。最普遍的PMQR基因是OQXB（25.58％），而6.98％有QEP基因。 Klebsiella肺炎一般都有ESBL和PMQR基因。研究菌株中扩展光谱β-内酰胺酶基因的高患病率呼吁在使用β内酰胺抗生素在家禽饲料中进行警告。这是Morganella Morganii和从家禽粪便中分离的羊毛菌和血糖Adecarboxylata菌株发生的扩展谱β-内酰胺酶和质粒介导的喹啉抗基因的第一个报告。

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