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Endometrial tuberculosis among patients undergoing endometrial biopsy at Tikur Anbesa specialized hospital, Addis Ababa, Ethiopia

机译：在埃塞俄比亚亚的斯亚贝巴亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲省患有子宫内膜患者的子宫内膜结核

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Abstract Background Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading to infertility and its incidence closely parallels with the overall prevalence of tuberculosis (TB) in a community. Its magnitude is underreported because diagnosis is difficult and requires invasive techniques. In this study we determined the prevalence of endometrial tuberculosis and characterized isolates among women who underwent endometrial biopsy for evaluation of various conditions at a Tikur Anbessa Specialized Hospital (TAHS), Addis Ababa, Ethiopia. Methods A cross sectional study was conducted on 152 consecutive gynecologic patients who underwent endometrial biopsy for different gynecologic diseases. Endometrial tissue taken for routine histopathology examination was shared after informed consent was obtained from the patient and subjected to polymerase chain reaction (PCR) and culture for Mycobacterium tuberculosis (Mtb). Results The prevalence of endometrial TB in this study by IS1081PCR was 4.6% (7/152) while culture proven endometrial TB was 2.6% (4/152). However, histological examination identified only 2/152 (1.3%) endometrial tuberculosis. While all culture proven TB samples were also PCR positive for Mtb, only one histologic proven endometrial TB was culture and PCR positive. All of the four isolates by culture were M. tuberculosis. Conclusion This study has shown that the magnitude of endometrial TB is fairly high in gynecologic patients visiting outpatient departments for various complaints and PCR detects more cases than culture or Histopathology.
机译：摘要背景女性生殖结核（FGTB）被众所周知导致严重的输卵管疾病导致不孕症及其发病率与社区中结核病（TB）的总体流行性紧密相似。由于诊断困难并且需要侵入性技术，其幅度被报告。在这项研究中，我们确定了子宫内膜结核病的患病率，并表现出在埃涅替亚州伊富米亚的亚·阿巴巴（Tahs），埃塞俄比亚亚的斯·阿巴巴的各种条件下进行子宫内膜活检的妇女患有子宫内膜活检的患者。方法对横截面研究进行横截面研究，对不同妇科疾病进行子宫内膜活检的152名连续妇科患者进行。在从患者获得知情同意后共享用于常规组织病理学检查的子宫内膜组织，并进行聚合酶链式反应（PCR）和分枝杆菌结核病（MTB）的培养物。结果IS1081PCR本研究中的子宫内膜结核病的患病率为4.6％（7/152），而培养物证明子宫内膜TB为2.6％（4/152）。然而，组织学检查仅确定了2/152（1.3％）子宫内膜结核。虽然所有文化证明的TB样品也是MTB的PCR阳性，但只有一个组织学证明子宫内膜TB是培养和PCR阳性。培养的所有四分之一的分离物都是结核病。结论本研究表明，妇科患者的子宫内膜结核病幅度相当高，妇科患者访问门诊部门，各种投诉和PCR检测多种培养物或组织病理学。

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