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Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno2,3-dpyrimidine Antifolates

机译：有效的双胸腺酯合酶和二氢氢醇还原酶抑制剂：经典和无菌2-氨基-4-氧代-5-芳硫基取代 - 6-甲基硫磺酸盐2,3-D嘧啶

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Aleem Gangjee; Yibin Qiu; Wei Li; Roy L. Kisliuk;
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1. Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: Classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates [J] . Gangjee A, Qiu YB, Li W, Journal of Medicinal Chemistry . 2008,第18期

机译：有效的双胸苷酸合酶和二氢叶酸还原酶抑制剂：经典和非经典的2-氨基-4-氧代-5-芳硫基取代的6-甲基硫代[2,3-d]嘧啶抗叶酸剂
2. 2,4-Diamino-5-methyl-6-substituted arylthio-furo(2,3-d)pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. [J] . Gangjee A, Jain HD, Phan Bioorganic and medicinal chemistry . 2010,第2期

机译：2,4-二氨基-5-甲基-6-取代的芳硫基-呋喃（2,3-d）嘧啶类化合物是新型的经典和非经典抗叶酸药，它们是潜在的双重胸苷酸合酶和二氢叶酸还原酶抑制剂。
3. 2,4-Diamino-5-methyl-6-substituted arylthio-furo(2,3-d)pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. [J] . Gangjee A, Jain HD, Phan Bioorganic and medicinal chemistry . 2010,第2期

机译：2,4-二氨基-5-甲基-6-取代的芳硫基 - 呋喃（2,3-D）嘧啶作为新型经典和非生物化防雾，作为潜在的双胸苷合酶和二氢醇还原酶抑制剂。
4. Probing drug mechanism of action via cellular metabolomics and fluxomics: An unexpected effect of the dihydrofolate reductase inhibitor trimethoprim [C] . Yun Kyung Kwon, Wenyun Lu, Joshua Rabinowitz ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：细胞代谢组学探测作用的药物机制：二氢酚还原酶抑制剂的意外效果Trimethoprim
5. Mechanistic and structure-function analysis of thymidylate synthase-dihydrofolate reductase from protozoal parasites: Implications for the development of non-active site inhibitors. [D] . Atreya, Chloe E. 2004

机译：原生动物寄生虫胸苷酸合酶-二氢叶酸还原酶的机制和结构功能分析：对非活性位点抑制剂的发展的影响。
6. Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno23-dpyrimidine Antifolates [O] . Aleem Gangjee, Yibin Qiu, Wei Li, -1

机译：有效的双胸苷酸合酶和二氢叶酸还原酶抑制剂：经典和非经典的2-氨基-4-氧代-5-氧代-芳硫基取代的6-甲基硫代23-d嘧啶类抗叶酸剂
7. Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents: Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo2, 3-dpyrimidine Antifolates [O] . -1

机译：胸苷合酶和二氢酚酸还原酶的双抑制剂作为抗肿瘤剂：古典和非生物吡咯的设计，合成和生物学评价2,3-D嘧啶防雾

Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno2,3-dpyrimidine Antifolates

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