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Thyroid hormones and male sexual function

机译:甲状腺激素和男性性功能

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摘要

The role of thyroid hormones in the control of erectile functioning has been only superficially investigated. The aim of the present study was to investigate the association between thyroid and erectile function in two different cohorts of subjects. The first one derives from the European Male Ageing Study (EMAS study), a multicentre survey performed on a sample of 3369 community-dwelling men aged 40-79years (mean 60±11years). The second cohort is a consecutive series of 3203 heterosexual male patients (mean age 51.8±13.0years) attending our Andrology and Sexual Medicine Outpatient Clinic for sexual dysfunction at the University of Florence (UNIFI study). In the EMAS study all subjects were tested for thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Similarly, TSH levels were checked in all patients in the UNIFI study, while FT4 only when TSH resulted outside the reference range. Overt primary hyperthyroidism (reduced TSH and elevated FT4, according to the reference range) was found in 0.3 and 0.2% of EMAS and UNIFI study respectively. In both study cohorts, suppressed TSH levels were associated with erectile dysfunction (ED). Overt hyperthyroidism was associated with an increased risk of severe erectile dysfunction (ED, hazard ratio=14 and 16 in the EMAS and UNIFI study, respectively; both p
机译:甲状腺激素的勃起功能的控制作用已经只是表面的影响。本研究的目的是调查的受试者的两个不同群组甲状腺和勃起功能之间的关联。从欧洲男性的第一个导出老龄化研究(EMAS研究),多中心调查3369社区居住的老年男子40-79years(平均60±11年)的样品进行的。第二个群体是一系列连续的参加我们的男科和性医学门诊在佛罗伦萨大学(UNIFI研究)性功能障碍3203名异性恋男性患者(平均年龄51.8±13.0年)。在EMAS研究所有受试者的促甲状腺激素(TSH)和游离甲状腺素(FT4)进行测试。同样,TSH水平在UNIFI研究的所有患者进行了检查,同时FT4只有当TSH导致外面的参考范围。公开原发性甲状腺功能亢进(还原TSH和高架FT4,根据该参考范围)在0.3发现和分别EMAS和UNIFI研究的0.2%。在两个研究组群,抑制TSH水平与勃起功能障碍(ED)相关联。公开亢进用的严重勃起功能障碍(ED,分别在EMAS和UNIFI研究中,风险比= 14和16的风险增加相关联; P均

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