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Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole

机译：新型Schiff碱系列Schiff碱系列的合成，光谱表征及抗菌活性，来自4-氨基丙氨酸和2-氨基苯并咪唑

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Background and objective: Compounds having imine or azomethine (–C=N–) functional group are known as Schiff bases. Schiff bases compounds are found to be an active pharmacophore for the design and development of various bioactive lead compounds. In this study, several new Schiff base compounds have been synthesized and characterized.Methods: Williamson ether synthesis process has been used to synthesize -alkyloxy and substituted benzyloxy of benzaldehyde. Differently substituted ether benzaldehydes used to react with 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in one hand and 1H-benzo[d]imidazol-2-amine on the other hand to produce Schiff base compounds.Results: Synthesized ether derivative compounds (3a-e) were converted to new series of Schiff bases (4a-e and 5a-e) by condensation of equal molar amounts of compounds (3a-e) with different heterocyclic amines dissolved in absolute ethanol. All synthesized compounds were confirmed by (IR, 1H-NMR, and 13CNMR) spectroscopy. All synthesized compounds were evaluated for antibacterial activities in vitro against Gram-positive and Gram-negative bacteria.Conclusion: All compounds were purely synthesized, and all compounds were indicated growth inhibition against Escherichia coli, and Staphylococcus aureus, respectively with different inhibition zones staring from 13 to 33 mm.
机译：背景和目的：具有亚胺或氮杂胺（-C = N-）官能团的化合物称为Schiff碱。 Schiff碱基化合物被发现是一种活性药物，用于各种生物活性铅化合物的设计和开发。在这项研究中，已经合成并表征了几种新的Schiff基础化合物。方法：威廉森醚合成方法已用于合成 - 烯氧基和苯甲醛取代苄氧基。用于在一手中与4-氨基-1,5-二甲基-2-苯基-1,2-二氢-3-pyrozol-3-一体反应的不同取代的醚苯甲醛。1H-苯并[D]咪唑-2-胺另一方面，生产席夫碱化合物。结果：通过溶解在绝对乙醇中的不同杂环胺的等摩尔量（3a-e）缩合，将合成的醚衍生物化合物（3a-e）转化为新的Schiff碱（4a-e和5a-e）。通过（IR，1H-NMR和13CNMR）光谱证实所有合成的化合物。评价所有合成的化合物，用于对革兰氏阳性和革兰氏阴性细菌体外的抗菌活性。结论：纯度合成所有化合物，并分别表明对大肠杆菌和金黄色葡萄球菌的生长抑制，分别具有不同的抑制区，凝视为13至33mm。

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