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A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap

机译：头孢曲松诱导的急性广义蛋白诱导脓疱疮/广义脓疱性牛皮癣重叠的情况

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摘要

Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this report the authors have reported a 40-year-old male patient with primary syphilis who developed generalized pustular dermatosis after the use of ceftriaxone. On the third day after ceftriaxone treatment, complete regression of the syphilis lesions was reached. While on the sixth day, erythematous pustular lesions accompanied with fever were observed on the whole body. A personal history of psoriasis and histopathological findings with psoriasiform changes and subcorneal pustule favored the diagnosis. After discontinuation of ceftriaxone, the patient’s condition slowly improved until he had plaque-type psoriasis 3 weeks later. A heterozygous c.115 + 6T>C missense substitution of IL36RN related to the pathogenesis of acute generalized exanthematous pustulosis/generalized pustular psoriasis was identified.
机译：急性广义蠕虫猪，其特征在于亚脑或浅层胸腔内脓疱，其药物诱导超过90％的病例。牛皮癣是一种由遗传易感人群不同条件引发的自身免疫性疾病。广义脓疱性牛皮癣是一种急性和严重的营养性临床形式，其通常发生在患有牛皮癣的患者中，经历加重因子。在本报告中，作者报告了一名40岁的男性患者，初级梅毒在使用Ceftriaxone后开发了广泛的脓疱皮肤病。在头孢曲松治疗后的第三天，达到了梅毒病变的完全回归。在第六天，在整个身体上观察到伴有发烧的红斑脓疱病变。牛皮癣和组织病理学发现的个人历史，具有牛皮癣变化和亚脑脓疱且诊断。在停药后，患者的病症缓慢改善，直到3周后斑块牛皮癣。鉴定了鉴定了杂合的C.115 + 6T> C致命替代IL36RN的替代术语。鉴定了急性广义吞噬脓疱疮/广义脓疱性牛皮癣的发病机制。

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