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Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance

机译：UGP2和CFL1表达水平在良性和恶性胰腺病变及其临床病理学意义中的表达及其临床病理学意义

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Abstract Background This study investigated UGP2 (uridine diphosphate-glucose pyrophosphorylase-2) and CFL1 (cofilin-1) expression in pancreatic ductal carcinoma (PDC), paracancerous tissue (PT), benign lesions (BL), and normal tissue (NT) and their clinicopathological significance. Methods Surgical specimens, which were collected from 106 cases of pancreatic ductal carcinoma, 35 cases of paracancerous tissues, 55 cases of benign lesions and 13 cases of normal pancreatic tissues, were fixed with 4% formaldehyde to prepare conventional paraffin-embedded sections. EnVision immunohistochemical was used to stain for UGP2 and CFL1. Kaplan-Meier survival analysis was performed to assess the correlation of expression pattern with survival. Results We found that positive UGP2 and CFL1 expression in PDC were significantly higher than those in PT, BL, and NT. In PT and BL with positive UGP2 and CFL1 expression, mild to severe atypical hyperplasia or intraepithelial neoplasia of grades II–III was observed in ductal epithelium. Positive UGP2 and CFL1 expression in cases with high differentiation, no lymph node metastasis, no surrounding invasion, and TNM (tumor-node-metastasis) staging I or/and II were significantly lower than those in cases with poor differentiation, lymph node metastasis, surrounding invasion, and TNM stage III and/or IV. Positive UGP2 expression in male patients was significantly lower than that in female patients. UGP2 and CFL1 expression in PDC were positively correlated. Kaplan-Meier survival analysis showed the degree of differentiation, tumor maximal diameter, TNM stage, lymph node metastasis, and surrounding invasion, and UGP2 and CFL1 expression were closely related to the average survival time of patients with PDC. The survival time of patients with positive UGP2 and CFL1 expression was significantly shorter than that of patients with negative expression. Cox multivariate analysis showed that poor differentiation, tumor maximal diameter ≥ 3 cm, TNM stage III or IV, lymph node metastasis, surrounding invasion, and positive UGP2 and CFL1 expression was negatively correlated with the postoperative survival rate and positively correlated with the mortality of patients with PDC. Conclusion Positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer.
机译：摘要背景本研究研究了胰腺导管癌（PDC），副血管组织（PT），良性病变（BL）和正常组织（NT）和正常组织（NT）中的UGP2（尿苷二磷酸葡萄糖焦磷酸酶-2）和CFL1（Cofilin-1）表达，良性病变（NT）和正常组织（NT）和他们的临床病理学意义。方法从106例胰腺导管癌中收集的手术标本，副病变35例，良性病变55例，13例正常胰腺组织，用4％甲醛固定，制备常规的石蜡包埋段。 Envision免疫组织化学用于染色UGP2和CFL1。进行Kaplan-Meier存活分析以评估表达模式与存活的相关性。结果发现PDC中的阳性UGP2和CFL1表达明显高于Pt，B1和NT中的阳性UGP2和CFL1表达。在PT和BL具有正UGP2和CFL1表达中，在导管上皮细胞上观察到II-III等级III的轻度至严重的非典型增生或初始肿瘤。阳性UGP2和CFL1表达在高分化，没有淋巴结转移，没有周围侵袭和TNM（肿瘤 - 节点转移）分期I或/和II的分段显着低于分化差，淋巴结转移的病例，围绕入侵，TNM阶段III和/或IV。男性患者的阳性UGP2表达明显低于女性患者。 PDC中的UGP2和CFL1表达呈正相关。 Kaplan-Meier存活分析显示分化程度，肿瘤最大直径，TNM阶段，淋巴结转移和周围侵袭，并且UGP2和CFL1表达与PDC患者的平均存活时间密切相关。阳性UGP2和CFL1表达患者的存活时间明显短于阴性表达的患者。 Cox多变量分析表明，分化差，肿瘤最大直径≥3cm，TNM阶段III或IV，淋巴结转移，周围侵袭和阳性UGP2和CFL1表达与术后生存率呈负相关，并与患者死亡率正相关用pdc。结论UGP2和CFL1的阳性表达可用于胰腺癌中有价值的预后因素。

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