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首页> 外文OA文献 >Blood Lipids and the Incidence of Atrial Fibrillation: The Multi‐Ethnic Study of Atherosclerosis and the Framingham Heart Study
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Blood Lipids and the Incidence of Atrial Fibrillation: The Multi‐Ethnic Study of Atherosclerosis and the Framingham Heart Study

机译：血脂和心房颤动的发生率：动脉粥样硬化的多民族研究和弗雷明汉心脏研究。

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BACKGROUND: Dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. Its role in the etiology of atrial fibrillation (AF) is uncertain.METHODS AND RESULTS: We studied 7142 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study who did not have prevalent AF at baseline and were not on lipid-lowering medications. Total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, and triglycerides were measured using standard procedures. Incident AF during follow-up was identified from hospital discharge codes; review of medical charts; study electrocardiograms; and, in MESA only, Medicare claims. Multivariable Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals of AF by clinical categories of blood lipids in each cohort. Study-specific results were meta-analyzed using inverse of variance weighting. During 9.6 years of mean follow-up, 480 AF cases were identified. In a combined analysis of multivariable-adjusted results from both cohorts, high levels of high-density lipoprotein cholesterol were associated with lower AF risk (hazard ratio 0.64, 95% CI 0.48 to 0.87 in those with levels u3e /=60 mg/dL versus u3c 40 mg/dL), whereas high triglycerides were associated with higher risk of AF (hazard ratio 1.60, 95% CI 1.25 to 2.05 in those with levels u3e /=200 mg/dL versus u3c 150 mg/dL). Total cholesterol and low-density lipoprotein cholesterol were not associated with the risk of AF.CONCLUSION: In these 2 community-based cohorts, high-density lipoprotein cholesterol and triglycerides but not low-density lipoprotein cholesterol or total cholesterol were associated with the risk of AF, accounting for other cardiometabolic risk factors.
机译：背景：血脂血症是动脉粥样硬化和冠状病发展的主要贡献者。它在心房颤动的病因（AF）中的作用是不确定的。方法和结果：我们研究了来自动脉粥样硬化（MESA）的多种族研究的7142名男女和弗拉明汉心脏研究没有普遍存在的AF在基线上不在降脂药物上。使用标准程序测量总胆固醇，高密度脂蛋白和低密度脂蛋白胆固醇和甘油三酯。随访期间的入射AF是从医院排放代码识别的;审查医疗图表;研究心电图;而且，在Mesa，Medicare索赔。多变量的Cox比例危害模型用于估算每个群组中血脂类别的危险比率和95％的AF置信度。使用方差加权的逆逆分析了特异性结果。在9.6年的平均随访期间，确定了480例案件。在对群组的多变量调整的结果的组合分析中，高水平的高密度脂蛋白胆固醇与降低的AF风险（危险比0.64,95％CI 0.48至0.87，在水平 U3E / = 60mg / d1中与 U3C 40 mg / dl），而高甘油三酯与AF的风险较高（危险比1.60,95％CI 1.25至2.05，其中 U3E / = 200 mg / DL与 U3C 150 mg / dl）的风险。总胆固醇和低密度脂蛋白胆固醇与AF的风险无关：结论：在这2个基于群落的群体中，高密度脂蛋白胆固醇和甘油三酯，但不是低密度脂蛋白胆固醇或总胆固醇与风险有关AF，占其他心肌镜危险因素。

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