The authors aimed to analyze the relationship between subclinical renal damage, defined as the presence of microalbuminuria or an estimated glomerular filtration rate (eGFR) between 30 mL/min/1.73 m(2) and 60 mL/min/1.73 m(2) and short-term blood pressure (BP) variability, assessed as average real variability (ARV), weighted standard deviation (SD) of 24-hour BP, and SD of daytime and nighttime BP. A total of 328 hypertensive patients underwent 24-hour ambulatory BP monitoring, 24-hour albumin excretion rate determination, and eGFR calculation using the Chronic Kidney Disease Epidemiology Collaboration equation. ARV of 24-hour systolic BP (SBP) was significantly higher in patients with subclinical renal damage (P=.001). This association held (P=.04) after adjustment for potential confounders. In patients with microalbuminuria, ARV of 24-hour SBP, weighted SD of 24-hour SBP, and SD of daytime SBP were also independently and inversely related to eGFR. These results seem to suggest that in essential hypertension, short-term BP variability is independently associated with early renal abnormalities.
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机译：作者旨在分析亚临床肾脏损害之间的关系，定义为存在微量白蛋白尿或估计的肾小球滤过率（eGFR）在30mL / min / 1.73m（2）和60mL / min / 1.73m（2）之间以及短期血压（BP）变异性，评估为平均真实变异性（ARV），24小时BP的加权标准差（SD）以及白天和夜间BP的SD。总共328位高血压患者接受了24小时动态血压监测，24小时白蛋白排泄率测定以及使用慢性肾脏病流行病学协作方程计算eGFR。亚临床性肾损害患者的24小时收缩压（SBP）的ARV显着更高（P = .001）。在对潜在的混杂因素进行调整之后，该协会成立了（P = .04）。在微量白蛋白尿患者中，24小时SBP的ARV，24小时SBP的加权SD和白天SBP的SD也与eGFR呈负相关。这些结果似乎表明，在原发性高血压中，短期BP变异性与早期肾脏异常独立相关。
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