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首页> 外文OA文献 >Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro
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Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

机译：利巴韦林拮抗嘧啶2'，3'-双脱氧核苷的抑制作用，但增强嘌呤2'，3'-双脱氧核苷对人免疫缺陷病毒体外复制的抑制作用

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摘要

The combined antiviral effects of various 2',3'-dideoxynucleosides and ribavirin on the replication of human immunodeficiency virus type 1 in MT-4 cells have been examined. Ribavirin antagonized the antiviral activity of the pyrimidine 2',3'-dideoxynucleosides (3'-azido-2',3'-dideoxythymidine, 2',3'-dideoxythymidin-2'-ene, 2',3'-dideoxycytidine, and 2',3'-dideoxycytidin-2'-ene), but enhanced the antiviral activity of the purine 2',3'-dideoxynucleosides (2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine). Combinations of the 2',3'-dideoxynucleosides with each other were also examined. These combinations resulted in an additive to subsynergistic effect.
机译：已经检查了各种2'，3'-二脱氧核苷和利巴韦林对MT-4细胞中1型人类免疫缺陷病毒复制的联合抗病毒作用。利巴韦林拮抗嘧啶2'，3'-二脱氧核苷（3'-叠氮基2'，3'-二脱氧胸苷，2'，3'-二脱氧胸苷2'-烯，2'，3'-二脱氧胞苷，和2'，3'-二脱氧胞苷-2'-烯），但增强了嘌呤2'，3'-二脱氧核苷（2'，3'-二脱氧腺苷和2'，3'-二脱氧鸟苷）的抗病毒活性。还检查了2'，3'-二脱氧核苷的相互结合。这些组合导致亚协同效应的加和。

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