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Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment

机译：激动剂抗4-1BB加上中和性抗CTLA-4或-PD-L1通过在肿瘤微环境中抢救垂死的功能异常的CD8 + T细胞来协同促进肿瘤消退

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入库时间 2022-08-20 20:28:04

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1. Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment [J] . Brendan Horton, Jason B Williams, Stefani Spranger, Journal for ImmunoTherapy of Cancer . 2015,第S2期

机译：激动剂抗4-1BB加上中和性抗CTLA-4或-PD-L1通过在肿瘤微环境中抢救垂死的功能异常的CD8 + T细胞来协同促进肿瘤消退
2. Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regression of established tumors [J] . Brendan Horton, Stefani Spranger, Jason Williams, Journal for ImmunoTherapy of Cancer . 2014,第S3期

机译：激动剂4-1bb抗体与针对肿瘤微环境中CD8 + T细胞上CTLA-4，PD-L1或LAG-3 ACT的抑制性抗体联合使用，并协同促进已建立肿瘤的消退
3. Variable density of CD8+ and CD25+ programmed cell death-1 (PD-1) ligand (PD-L1) CD4+ T cells within the tumor microenvironment causes differential responses to the PD-1/PD-L1 blockade [J] . Si-Pei Wu, Yi-Long Wu Journal for ImmunoTherapy of Cancer . 2015,第S2期

机译：肿瘤微环境中CD8 +和CD25 +程序性细胞死亡1（PD-1）配体（PD-L1）CD4 + T细胞的可变密度导致对PD-1 / PD-L1封锁的不同反应
4. Dysfunctional Cd8+ T Cells and the Immune Suppressive Tumor Microenvironment [D] . Williams, Jason Bruce. 2018

机译：功能异常的Cd8 + T细胞和免疫抑制肿瘤微环境
5. Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment [O] . Brendan Horton, Jason B Williams, Stefani Spranger, 2015

机译：激动剂抗4-1BB加上中和性抗CTLA-4或-PD-L1通过在肿瘤微环境中抢救垂死的功能异常的CD8 + T细胞来协同促进肿瘤消退
6. Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regression of established tumors [O] . 2014

机译：激动剂4-1bb抗体与针对肿瘤微环境中CD8 + T细胞上CTLA-4，PD-L1或LAG-3 ACT的抑制性抗体联合使用，并协同促进已建立肿瘤的消退

Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment

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