• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA.
【2h】

Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA.

机译：受全氯乙烯污染的饮用水和罹患乳腺癌的风险：美国马萨诸塞州科德角的其他结果。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In 1998 we published the results of a study suggesting an association between breast cancer and perchloroethylene (PCE; also called tetrachloroethylene) exposure from public drinking water. The present case-control study was undertaken to evaluate this association further. The cases were composed of female residents of eight towns in the Cape Cod region of Massachusetts who had been diagnosed with breast cancer from 1987 through 1993 (n = 672). Controls were composed of demographically similar women from the same towns (n = 616). Women were exposed to PCE when it leached from the vinyl lining of water distribution pipes from the late 1960s through the early 1980s. A relative delivered dose of PCE that entered a home was estimated using an algorithm that took into account residential history, water flow, and pipe characteristics. Small to moderate elevations in risk were seen among women whose exposure levels were above the 75th and 90th percentiles when 0-15 years of latency were considered (adjusted odds ratios, 1.5-1.9 for > 75th percentile, 1.3-2.8 for > 90th percentile). When data from the present and prior studies were combined, small to moderate increases in risk were also seen among women whose exposure levels were above the 75th and 90th percentiles when 0-15 years of latency were considered (adjusted odds ratios, 1.6-1.9 for > 75th percentile, 1.3-1.9 for > 90th percentile). The results of the present study confirm those of the previous one and suggest that women with the highest PCE exposure levels have a small to moderate increased risk of breast cancer.
机译：1998年，我们发表了一项研究结果，表明乳腺癌与公共饮用水中的四氯乙烯（PCE；也称为四氯乙烯）暴露之间存在关联。进行本病例对照研究以进一步评估该关联。这些病例由马萨诸塞州科德角地区八个城镇的女性居民组成，他们从1987年至1993年被诊断出患有乳腺癌（n = 672）。对照组由来自相同城镇的人口统计学上相似的妇女组成（n = 616）。从1960年代后期到1980年代初期，从水分配管的乙烯衬里浸出的PCE浸入了妇女。进入住宅的PCE的相对释放剂量是使用一种算法来估算的，该算法考虑了居住历史，水流量和管道特性。当考虑到0至15年的潜伏期时，暴露水平高于第75和第90个百分位的女性中风险有所升高（调整后的优势比，大于75个百分位数为1.5-1.9，大于90个百分位数为1.3-2.8）。 。结合当前研究和先前研究的数据，当考虑到潜伏期为0-15年时，暴露水平高于第75和第90个百分位的女性中，患病风险也有小到中度升高（调整后的优势比为1.6-1.9） > 75％，大于90％为1.3-1.9）。本研究的结果证实了前一项研究的结果，并表明具有最高PCE暴露水平的女性患乳腺癌的风险小至中度增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号