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首页> 外文OA文献 >Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation
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Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation

机译：进食后鲤鱼（鲤鱼）瘦素表达增加，但禁食或饱食后却没有

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Leptin is a key factor in the regulation of food intake and is an important factor in the pathophysiology of obesity. However, more than a decade after the discovery of leptin in mouse, information regarding leptin in any nonmammalian species is still scant. We report the identification of duplicate leptin genes in common carp (Cyprinus carpio). The unique gene structure, the conservation of both cysteines that form leptin's single disulfide bridge, and stable clustering in phylogenetic analyses substantiate the unambiguous orthology of mammalian and carp leptins, despite low amino acid identity. The liver is a major yet not the only site of leptin expression. However, neither 6 d nor 6 wk of fasting nor subsequent refeeding affected hepatic leptin expression, although the carp predictably shifted from carbohydrate to lipid metabolism. Animals that were fed to satiation grew twice as fast as controls; however, they did not show increased leptin expression at the termination of the study. Hepatic leptin expression did, however, display an acute and transient postprandial increase that follows the postprandial plasma glucose peak. In summary, leptin mRNA expression in carp changes acutely after food intake, but involvement of leptin in the long-term regulation of food intake and energy metabolism was not evident from fasting for days or weeks or long-term feeding to satiation. These are the first data on the regulation of leptin expression in any nonmammalian species.
机译：瘦素是调节食物摄入量的关键因素，并且是肥胖症病理生理学中的重要因素。然而，在小鼠中发现瘦素十多年之后，有关任何非哺乳动物物种中瘦素的信息仍然很少。我们报告了鲤鱼中鲤鱼瘦素基因的重复鉴定。独特的基因结构，形成瘦素单二硫键的两个半胱氨酸的保守性以及系统发育分析中的稳定聚类，尽管氨基酸同一性低，但仍能证实哺乳动物和鲤鱼瘦素的无歧义性。肝脏是瘦素表达的主要部位，但不是唯一部位。然而，尽管可预测鲤鱼从碳水化合物转变为脂质代谢，但禁食6 d或6 wk或随后再喂养均不会影响肝瘦素的表达。饱食的动物的生长速度是对照组的两倍。然而，他们在研究结束时并未显示出瘦素表达的增加。然而，肝瘦素的表达确实显示出餐后血浆葡萄糖峰值之后的餐后急性和短暂的增加。总之，在进食后鲤鱼中瘦素的mRNA表达会急剧变化，但是从禁食几天或几周或长期进食到饱食，瘦素未参与长期的食物摄入和能量代谢调节。这些是有关任何非哺乳动物物种中瘦素表达调控的第一批数据。

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