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Corticotrophin-Releasing Hormone Type 1 Receptor Gene (CRHR1) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients

机译：促肾上腺皮质激素释放激素1型受体基因（CRHR1）变异体预测小儿受伤患者的创伤后应激障碍发作和病程

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Posttraumatic stress disorder (PTSD) is a common and disabling anxiety disorder that may occur in the aftermath of exposure to potentially traumatic life events. PTSD is moderately heritable, but few specific molecular variants accounting for this heritability have been identified. Genes regulating the hypothalamic-pituitary-adrenal (HPA) axis, such as corticotrophin-releasing hormone type 1 receptor gene (CRHR1), have been implicated in traumatic-stress related phenotypes but have yet to be studied in relation to PTSD. The present study sought to examine the relation between 9 single nucleotide polymorphisms (SNPs) in the CRHR1 gene and posttraumatic stress symptoms in a prospective study of pediatric injury patients (n = 103) who were first assessed in the acute aftermath of their injury at the hospital. Results indicated that multiple SNPs were associated with acute symptoms at a univariate level, and after correction for multiple testing, rs12944712 was significantly related to acute PTSD symptoms. Longitudinal latent growth curve analyses suggest that rs12944712 is also related to both acute symptom level and trajectory of symptoms over time. The present study adds support for the role of CRHR1 in the stress response following potentially traumatic event exposure in youth. It should be noted that the sample size in this study was small, and therefore statistical power was low; following, results from this study should be considered preliminary. Although results are not definitive, the findings from this study warrant future replication studies on how variation in this gene relates to response to traumatic event exposure in youth.
机译：创伤后应激障碍（PTSD）是一种常见的致残性焦虑症，可能发生在暴露于潜在的创伤性生活事件后。 PTSD具有中等遗传性，但几乎没有发现可解释这种遗传性的特定分子变异。调节下丘脑-垂体-肾上腺（HPA）轴的基因，例如促肾上腺皮质激素释放激素1型受体基因（CRHR1），已与创伤压力相关的表型有关，但尚未与PTSD相关地进行研究。本研究旨在对儿童受伤患者（n = 103）的前瞻性研究中的CRHR1基因中的9个单核苷酸多态性（SNPs）与创伤后应激症状之间的关系进行研究，这些患者首先在急性损伤后评估。医院。结果表明，多个SNP与单变量水平的急性症状相关，并且经过多次测试校正后，rs12944712​​与急性PTSD症状显着相关。纵向潜在生长曲线分析表明，rs12944712​​还与急性症状水平和症状随时间的轨迹相关。本研究增加了对CRHR1在青年潜在的创伤事件暴露后应激反应中的作用的支持。应该注意的是，这项研究的样本量很小，因此统计功效很低。接下来，这项研究的结果应被认为是初步的。尽管结果尚不确定，但这项研究的结果值得将来进行重复研究，研究该基因的变异与青年对创伤事件的反应之间的关系。

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