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首页> 外文OA文献 >Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection
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Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection

机译：甲状腺乳头状癌预防性单侧中央颈部切除术后转移淋巴结转移率对刺激甲状腺球蛋白水平的意义

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Background: Prognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. Methods: To be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved) × 100. They were categorized into group 1 (CLNR 66.67%) (n = 22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg. Results: Young age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (P
机译：背景：甲状腺乳头状癌（PTC）的转移性中央淋巴结比率（CLNR）的预后意义仍然未知。由于放射碘消融后手术后可检测到的刺激性甲状腺球蛋白（DsTg）可能意味着持续性或复发性疾病，因此我们评估了接受单侧预防性中央颈清扫术的PTC患者的CLNR与DsTg率之间的相关性。方法：为符合分析要求，预防性中央颈淋巴结清扫标本必须包含≥3个中央淋巴结（CLN），且转移灶≥1个。在129个样本中，有51个（39.5％）符合条件。 CLNR的计算方式如下：（转移性CLN数/检索到的CLN数）×100。它们被分类为第1组（CLNR 66.67％）（n = 22）。放射性碘消融后6个月测量消融后sTg水平。进行多变量分析以鉴定消融后DsTg的因素。结果：年轻，高大的颈部肿胀，大的肿瘤大小，进展的肿瘤，淋巴结，转移系统（TNM）分期以及大量的转移性CLN与高CLNR显着相关（P

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