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首页> 外文OA文献 >Immediate Memory and Electrophysiologic Effects of Prefrontal Cortex Transcranial Direct Current Stimulation on Neurotypical Individuals and Individuals with Chronic Traumatic Brain Injury: A Pilot Study.
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Immediate Memory and Electrophysiologic Effects of Prefrontal Cortex Transcranial Direct Current Stimulation on Neurotypical Individuals and Individuals with Chronic Traumatic Brain Injury: A Pilot Study.

机译：前额叶皮层经颅直接电流刺激对慢性创伤性脑损伤的神经型个体和个体的即刻记忆和电生理效应：一项试验性研究。

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PURPOSE/AIM: Memory impairment post-TBI is common, frequently persistent, and functionally debilitating. The purposes of this pilot study were to assess and to compare immediate behavioral auditory working memory and electrophysiologic effects of three different, randomized, conditions of left dorsolateral prefrontal cortex (LDLPFC) transcranial direct current stimulation (tDCS) applied to four neurotypical adults and four adults with chronic traumatic brain injury (TBI). MATERIALS/METHODS: Pre- and post- anodal, cathodal, and sham tDCS auditory memory performance, auditory event-related potentials (P300 amplitude and latency) and power of alpha and theta EEG bands were measured across individuals in each group. RESULTS: Post-anodal tDCS only, the neurotypical and TBI groups both demonstrated significantly improved immediate auditory memory function. Also post-anodal tDCS, the TBI group demonstrated significantly increased P300 amplitude versus post-sham tDCS. The neurotypical group demonstrated no pre- post tDCS electrophysiologic changes across conditions. CONCLUSIONS: These findings are consistent with findings of other studies of immediate tDCS effects on other types of memory in neurotypical individuals and in individuals with Parkinson's disease, Alzheimer's disease, and stroke and suggest that individuals with memory impairments second to chronic TBI may benefit from LDLPFC anodal tDCS. Pairing tDCS with traditional behavioral memory interventions may facilitate TBI rehabilitation outcomes and warrants continued investigation.
机译：目的/目的：TBI后的记忆障碍是常见的，经常持续存在，并且使人的身体功能下降。这项初步研究的目的是评估和比较三种不同的随机左侧左前额叶前额叶皮层（LDLPFC）经颅直流电刺激（tDCS）情况对四个神经型成年人和四个成年人的即时行为听觉工作记忆和电生理效应患有慢性创伤性脑损伤（TBI）。材料/方法：在每组个体中，测量了阳极和阳极之前，阳极之后，阴极和假tDCS的听觉记忆表现，与听觉事件相关的电位（P300振幅和潜伏期）以及α和theta脑电图谱带的强度。结果：仅在阳极后tDCS，神经型和TBI组均表现出显着改善的立即听觉记忆功能。同样在阳极后的tDCS中，TBI组证明了与假手术后的tDCS相比，P300振幅显着增加。神经型组在各种情况下均未显示tDCS发生前的电生理变化。结论：这些发现与其他关于tDCS对神经性个体以及帕金森氏病，阿尔茨海默氏病和中风个体中其他类型记忆的即时研究相关的其他研究结果一致，并提示记忆力减退仅次于慢性TBI的个体可能会受益于LDLPFC阳极tDCS。将tDCS与传统的行为记忆干预措施配对可以促进TBI的康复结果，并需要继续进行调查。

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