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Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

机译：新型取代硼硅酸盐生物活性玻璃及其微晶玻璃衍生物的设计与性能

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Three novel borosilicate bioactive glasses (BBGs) of general formula of 0.05Na2O·0.35x·0.20B2O3·0.40SiO2 (molar ratio, where x = MgO or CaO or SrO) were prepared and used to investigate the effect of crystallization on their properties including cytotoxicity. The three postmelt compositions were determined using X-ray fluorescence spectroscopy, and crystallization events were studied using differential thermal analysis and X-ray diffraction. This information was used to determine heat treatments to prepare glass-ceramics by controlled crystallization. X-ray diffraction analysis and Fourier transform infrared spectroscopy showed that, after higher heat treatment temperatures (800–900 °C), borosilicate bioactive glass-ceramics (BBGCs) contained mainly borate and silicate crystalline phases. Specifically, BBG-Mg, BBG-Ca, and BBG-Sr glass-ceramics detected the presence of magnesium silicate-Mg2(SiO3)2 and magnesium borate-Mg2B2O5; wollastonite-2M-CaSiO3 and calcium borate-Ca(BO2)2; and strontium silicate-SrSiO3 and strontium borate-Sr2B2O5, respectively. In vitro cytotoxicity tests were performed using the mouse fibroblast cell line (L929). Glass and glass ceramic at concentrations lower than 50 mg/mL did not exhibit any level of cytotoxicity when compared with the control. However, quantitative evaluation indicated that greater cell growth occurred in the presence of materials with crystalline phases. Control of BBGs crystallization may therefore be used to influence the biocompatibility of these glass-ceramic systems.
机译：制备了三种新型的通式为0.05Na2O·0.35x·0.20B2O3·0.40SiO2（摩尔比，其中x = MgO或CaO或SrO）的硼硅酸盐生物活性玻璃，并用于研究结晶对其性能的影响，包括细胞毒性。使用X射线荧光光谱法确定了三种后熔组成，并使用差热分析和X射线衍射研究了结晶事件。该信息用于确定通过控制结晶制备玻璃陶瓷的热处理。 X射线衍射分析和傅立叶变换红外光谱显示，在较高的热处理温度（800-900°C）下，硼硅酸盐生物活性玻璃陶瓷（BBGC）主要包含硼酸盐和硅酸盐结晶相。具体地说，BBG-Mg，BBG-Ca和BBG-Sr玻璃陶瓷检测到存在硅酸镁-Mg2（SiO3）2和硼酸镁-Mg2B2O5。硅灰石2M-CaSiO3和硼酸钙-Ca（BO2）2;分别是硅酸锶-SrSiO3和硼酸锶-Sr2B2O5。使用小鼠成纤维细胞系（L929）进行了体外细胞毒性测试。与对照相比，浓度低于50 mg / mL的玻璃和玻璃陶瓷没有任何水平的细胞毒性。但是，定量评估表明，存在具有结晶相的材料时，细胞的生长更大。因此，BBGs结晶的控制可用于影响这些玻璃陶瓷系统的生物相容性。

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