• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition
【2h】

Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition

机译：年龄相关的线粒体功能障碍和运动对肠道菌群组成的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mitochondrial dysfunction is prevalent in the ageing gastrointestinal tract. We investigated whether mitochondrial function in ageing colonic crypts and exercise influence microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7 and 11 months, and bacterial profiling was achieved through 16S rRNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgAmut/mut and PolgA+/+ mice. Sedentary and exercised PolgAmut/mut mice had significantly higher levels of mitochondrial dysfunction than PolgA+/+ mice (78%, 77% and 1% of crypts, respectively). Bacterial profiles of sedentary PolgAmut/mut mice were significantly different from the sedentary PolgA+/+ mice, with increases in Lactobacillus and Mycoplasma, and decreases in Alistipes, Odoribacter, Anaeroplasma, Rikenella, Parabacteroides, Allobaculum in the PolgAmut/mut mice. Exercise did not have any impact upon gut mitochondrial dysfunction, however, exercise did increase gut microbiota diversity and significantly increasing bacterial genera Mucispirillum and Desulfovibrio. Mitochondrial dysfunction is associated with changes in the gut microbiota. Endurance exercise moderated some of these changes, establishing that environmental factors can influence gut microbiota despite mitochondrial dysfunction.
机译：线粒体功能障碍在衰老的胃肠道中普遍存在。我们调查了老化结肠隐窝和运动中的线粒体功能是否会影响小鼠的肠道微生物群落。在12个月时将12只PolgAmut / mut小鼠随机分为久坐和运动组。整个过程中，七只年龄匹配的PolgA + / +小鼠保持久坐。在第4、7和11个月时收集粪便样品，并通过16S rRNA测序分析获得细菌分析。对于PolgAmut / mut和PolgA + / +小鼠，在11个月时评估了结肠上皮隐窝的线粒体酶活性。久坐和运动的PolgAmut / mut小鼠的线粒体功能障碍水平明显高于PolgA + / +小鼠（分别为隐窝的78％，77％和1％）。久坐的PolgAmut / mut小鼠的细菌特征与久坐的PolgA + / +小鼠显着不同，其中乳酸菌和支原体增加，而PolgAmut / mut小鼠中的阿利斯贝氏菌，敖德罗杆菌，无形体，里克氏菌，副细菌，同种异体菌减少。锻炼对肠道线粒体功能障碍没有任何影响，但是，锻炼确实会增加肠道菌群多样性，并显着增加细菌属粘螺旋藻和脱硫弧菌。线粒体功能障碍与肠道菌群的变化有关。耐力运动缓解了其中的一些变化，证明尽管线粒体功能障碍，环境因素仍可影响肠道菌群。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号