• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERα Inhibition
【2h】

Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERα Inhibition

机译：Emodin and aloe-Emodin suppress Breast Cancer Cell proliferation through ERα Inhibition

页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The anthraquinones emodin and aloe-emodin are abundant in rhubarb. Several lines of evidence indicate that emodin and aloe-emodin have estrogenic activity as phytoestrogens. However, their effects on estrogen receptor α (ERα) activation and breast cancer cell growth remain controversial. The goal of this study is to investigate the effects and molecular mechanisms of emodin and aloe-emodin on breast cancer cell proliferation. Our results indicate that both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by downregulating ERα protein levels, thereby suppressing ERα transcriptional activation. Furthermore, aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ERα and increased ERα ubiquitination. Although emodin had similar effects to aloe-emodin, it was not capable of promoting HSP90/ERα dissociation and ERα ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ERα degradation. Although emodin might induce cytosolic ERα degradation, it primarily affected nuclear ERα distribution similar to the action of estrogen when protein degradation was blocked. In conclusion, our data demonstrate that emodin and aloe-emodin specifically suppress breast cancer cell proliferation by targeting ERα protein stability through distinct mechanisms. These findings suggest a possible application of anthraquinones in preventing or treating breast cancer in the future.
机译：大黄中蒽醌大黄素和芦荟大黄素含量很高。几条证据表明，大黄素和芦荟大黄素具有植物雌激素的雌激素活性。然而，它们对雌激素受体α（ERα）活化和乳腺癌细胞生长的影响仍存在争议。这项研究的目的是研究大黄素和芦荟大黄素对乳腺癌细胞增殖的影响及其分子机制。我们的结果表明，大黄素和芦荟大黄素都能够通过下调ERα蛋白水平来抑制乳腺癌细胞增殖，从而抑制ERα转录激活。此外，芦荟大黄素处理导致热休克蛋白90（HSP90）和ERα分离，并增加ERα泛素化。尽管大黄素与芦荟大黄素具有相似的作用，但它不能促进HSP90 /ERα的解离和ERα的泛素化。蛋白质分级分离结果表明，芦荟大黄素趋向于诱导胞质ERα降解。尽管大黄素可能诱导胞质ERα降解，但它主要影响核ERα的分布，类似于阻止蛋白质降解时雌激素的作用。总之，我们的数据表明，大黄素和芦荟大黄素通过不同机制靶向ERα蛋白稳定性，从而特异性抑制乳腺癌细胞增殖。这些发现表明，蒽醌可能会在将来预防或治疗乳腺癌中应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号