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Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia

机译：阿托伐他汀与非诺贝特对混合性高脂血症患者apoB-100和apoa-I动力学的影响

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Kinetics of apo B and apo AI were assessed in 8 patients with mixed hyperlipidemia at baseline and after 8 weeks of atorvastatin 80 mg q.d. and micronised fenofibrate 200 mg q.d. in a cross-over study. Both increased hepatic production and decreased catabolism of VLDL accounted for elevated cholesterol and triglyceride concentrations at baseline. Atorvastatin significantly decreased triglyceride, total, VLDL and LDL cholesterol and apo B concentrations (-65%, -36%, -57%, -40% and -33%, respectively, Ptextless0.05). Kinetic analysis revealed that atorvastatin stimulated the catabolism of apo B containing lipoproteins, enhanced the delipidation of VLDL1 and decreased VLDL1 production. Fenofibrate lowered triglycerides and VLDL cholesterol (-57% and -64%, respectively, Ptextless0.05) due to enhanced delipidation of VLDL1 and VLDL2 and increased VLDL1 catabolism. Changes of HDL particle composition accounted for the increase of HDL cholesterol during atorvastatin and fenofibrate (18% and 23%, Ptextless0.01). Only fenofibrate increased apo AI concentrations through enhanced apo AI synthesis (45%, Ptextless0.05). We conclude that atorvastatin exerts additional beneficial effects on the metabolism of apo B containing lipoproteins unrelated to an increase in LDL receptor activity. Fenofibrate but not atorvastatin increases apo AI production and plasma turnover.
机译：在基线时以及在阿托伐他汀80 mg q.d. 8周后，对8例混合性高脂血症患者的apo B和apo AI动力学进行了评估。和微粉非诺贝特200 mg q.d.在交叉研究中。肝产量的增加和VLDL分解代谢的降低均导致基线时胆固醇和甘油三酸酯浓度升高。阿托伐他汀显着降低甘油三酸酯，总甘油三酯，VLDL和LDL胆固醇以及apo B的浓度（分别为-65％，-36％，-57％，-40％和-33％，Ptextless0.05）。动力学分析表明，阿托伐他汀可刺激含载脂蛋白B的脂蛋白分解代谢，增强VLDL1的脱脂作用并降低VLDL1的产生。非诺贝特降低了甘油三酸酯和VLDL胆固醇（分别为-57％和-64％，Ptextless0.05），这是由于VLDL1和VLDL2的脱脂作用增强和VLDL1分解代谢增加。 HDL颗粒组成的变化是阿托伐他汀和非诺贝特期间HDL胆固醇增加的原因（分别为18％和23％，Ptextless0.01）。只有非诺贝特通过增强apo AI合成来增加apo AI浓度（45％，Ptextless0.05）。我们得出的结论是，阿托伐他汀对包含apo B的脂蛋白的代谢具有额外的有益作用，而脂蛋白与LDL受体活性的增加无关。非诺贝特而非阿托伐他汀可增加apo AI的产生和血浆更新。

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